The effect of surgical margin on cancer-specific survival in patients treated with nephron-sparing surgery

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dc.contributor.authorKizilay, F.
dc.contributor.authorEskidemir, U.
dc.contributor.authorBahceci, T.
dc.contributor.authorSimsir, A.
dc.contributor.authorOzdemir, H.
dc.contributor.authorSarsik, B.
dc.contributor.authorTurna, B.
dc.date.accessioned2020-12-01T12:09:08Z
dc.date.available2020-12-01T12:09:08Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Nephron-sparing surgery (NSS) is currently the recommended treatment modality for selected renal tumors. the prognostic significance of positive surgical margin (PSM) and surgical margin width (SMW) after NSS is controversial. Aim: To evaluate the effect of PSM and SMW on cancer-specific survival (CSS) in patients who underwent NSS. Materials and Methods: the pathological samples of 142 patients who underwent NSS were reviewed. Patients were divided into two groups with PSM and negative surgical margin (NSM), and after that those with PSM were divided into two groups according to SMW as those with 0.1-2 mm and those >2 mm. CSS was calculated using Kaplan-Meier method. Cox regression analysis was used to adjust the clinicopathologic variables. A P value < 0.05 was considered statistically significant. Results: Local recurrence rate and distant metastasis rate were higher in patients with PSMs than those with NSMs (P = 0.018 and P = 0.039, respectively). However, there was no significant difference between the two groups in terms of CSS. in the group with SMW 0.1-2 mm, the tumor diameter was longer (P = 0.018), enucleation number was higher (P = 0.026), and local recurrence was higher (P = 0.034) than the group with SMW > 2 mm. There was no significant difference between the two groups in terms of CSS. Conclusion: in patients who underwent NSS, PSMs and SMWs have a negative effect on local recurrence but have no significant effect on CSS.en_US
dc.identifier.doi10.4103/njcp.njcp_267_18en_US
dc.identifier.endpage1402en_US
dc.identifier.issn1119-3077
dc.identifier.issue10en_US
dc.identifier.pmid31607729en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1396en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_267_18
dc.identifier.urihttps://hdl.handle.net/11454/63326
dc.identifier.volume22en_US
dc.identifier.wosWOS:000506577700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNephron-sparing surgeryen_US
dc.subjectpathologyen_US
dc.subjectprognosisen_US
dc.subjectrenal cell carcinomaen_US
dc.subjectsurvivalen_US
dc.titleThe effect of surgical margin on cancer-specific survival in patients treated with nephron-sparing surgeryen_US
dc.typeArticleen_US

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