The low levels of bone morphogenic protein-4 and its antagonist noggin in type 2 diabetes

Basit Öğe Kaydı
dc.contributor.authorYurekli, Banu Sarer
dc.contributor.authorKocabas, Gokcen Unal
dc.contributor.authorAksit, Murat
dc.contributor.authorKutbay, Nilufer Ozdemir
dc.contributor.authorSuner, Asli
dc.contributor.authorYurekli, Ismail
dc.contributor.authorCakir, Habib
dc.contributor.authorBozkaya, Giray
dc.contributor.authorCetinkalp, Sevki
dc.date.accessioned2019-10-27T10:05:13Z
dc.date.available2019-10-27T10:05:13Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective Bone morphogenic protein-4 (BMP-4) is a proinflammatory cytokine which is controlled by BMP-4 antagonists. Our aim was to investigate the levels of BMP-4 and its antagonists, noggin and matrix Gla protein (MGP), in prediabetes and diabetes. Design One hundred and forty-two type 2 diabetic, 32 prediabetic, and 58 control subjects participated in this cross-sectional study. BMP-4, noggin, and MGP were measured with the ELISA method. Results There was a significant difference between the three groups in relation to sex, hypertension, fasting plasma glucose, HbA1c, lipid profiles, and diastolic blood pressure (p < 0.05). BMP-4 levels were significantly lower in the diabetic group compared to the control group (108.5 and 127.5 ng/mL, respectively, p < 0.001 diabetes vs. control). Noggin levels were significantly lower in the diabetic group compared to the prediabetic and control groups (10.5, 11.5, and 12.0 ng/mL, as median, respectively, p < 0.001; diabetes vs. control, p = 0.002; diabetes vs. prediabetes). BMP-4 was associated significantly with noggin in the entire study population (beta coefficient = 0.796, p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve was 0.708 (95% CI 0.551-0.864, p = 0.011) for BMP-4 levels. The optimal cutoff value of BMP-4 for detecting albuminuria was 118.5 ng/mL for which sensitivity was 71.4% and specificity was 66.4%. Conclusions BMP-4 and noggin levels were lower in the diabetic group. High BMP-4 levels were significantly associated with albuminuria. Further studies are warranted to determine the role of BMP-4 in the pathogenic processes underlying albuminuria and hyperglycemia in patients with type 2 diabetes.en_US
dc.description.sponsorshipEge University Scientific Research Project Committee [2015-TIP-034]en_US
dc.description.sponsorshipThis work was supported by the Ege University Scientific Research Project Committee, with project number 2015-TIP-034.en_US
dc.identifier.doi10.1007/s42000-018-0041-5en_US
dc.identifier.endpage253en_US
dc.identifier.issn1109-3099
dc.identifier.issn2520-8721
dc.identifier.issue2en_US
dc.identifier.pmid29943307en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1007/s42000-018-0041-5
dc.identifier.urihttps://hdl.handle.net/11454/30330
dc.identifier.volume17en_US
dc.identifier.wosWOS:000438142000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer International Publishing Agen_US
dc.relation.ispartofHormones-International Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBMP-4en_US
dc.subjectAntagonistsen_US
dc.subjectUrinary albumin excretionen_US
dc.titleThe low levels of bone morphogenic protein-4 and its antagonist noggin in type 2 diabetesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu