Does ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?

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dc.contributor.authorAydogdu I.
dc.contributor.authorIlbey Y.O.
dc.contributor.authorCoban G.
dc.contributor.authorEkin R.G.
dc.contributor.authorMirapoglu S.L.
dc.contributor.authorCay A.
dc.contributor.authorKiziltan H.S.
dc.contributor.authorEkin Z.Y.
dc.contributor.authorSilay M.S.
dc.contributor.authorSemerci M.B.
dc.date.accessioned2019-10-27T08:01:08Z
dc.date.available2019-10-27T08:01:08Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: We investigate the protective and therapeutic effects of ozone therapy (OT) in radiotherapy (RT)-induced testicular damage. Methods: Thirty healthy adult male Wistar rats divided into five groups consisting of six animals each as follows: (1) Control (C), (2) RT, (3) OT, (4) OT + RT, and (5) RT + OT group. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) levels were evaluated. Results: RT caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase, and GPx levels were significantly lower in the RT group when compared to the control group. Pre and postRT OT significantly increased GSH, SOD, catalase, and GPx levels and decreased TBARS level. Furthermore, testicular weight and Johnsen score were increased with OT. Conclusions: The present study showed that OT is protective and therapeutic in radiation-induced testicular damage. OT may be beneficial to the patients who underwent RT. © 2019 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.en_US
dc.identifier.doi10.4103/jcrt.JCRT_322_17en_US
dc.identifier.endpageS81en_US
dc.identifier.issn0973-1482
dc.identifier.issue8en_US
dc.identifier.pmid30900625en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageS76en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_322_17
dc.identifier.urihttps://hdl.handle.net/11454/24920
dc.identifier.volume15en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOzone treatmenten_US
dc.subjectradiationen_US
dc.subjectradiotherapyen_US
dc.subjecttesticular histopathologyen_US
dc.subjecttestisen_US
dc.titleDoes ozone administration have a protective or therapeutic effect against radiotherapy-induced testicular injury?en_US
dc.typeArticleen_US

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