The effect of previous psychotic mood episodes on cognitive impairment in euthymic bipolar patients

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dc.contributor.authorBora, Emre
dc.contributor.authorVahip, Simavi
dc.contributor.authorAkdeniz, Fisun
dc.contributor.authorGonul, Ali Saffet
dc.contributor.authorEryavuz, Ayse
dc.contributor.authorOgut, Melise
dc.contributor.authorAlkan, Muge
dc.date.accessioned2019-10-27T19:33:02Z
dc.date.available2019-10-27T19:33:02Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Cognitive dysfunctions in several domains were proposed to be trait markers of bipolar patients. The aim of this study was to evaluate the effect of previous psychotic features on neuropsychological measures, including sustained attention, in remitted bipolar patients. Methods: The study participants were 40 euthymic psychotic, 25 non-psychotic bipolar I patients and 30 healthy control subjects. Participants were assessed with a battery of neuropsychological tests targeting attention, executive functions, psychomotor speed, verbal learning and memory. Results: Euthymic psychotic bipolar patients performed worse than controls on most of the measures, after controlling for the confounding effects of education, age and residual symptoms. Non-psychotic patients were also impaired on tasks of attention, fluency and psychomotor speed. 'Number of Wisconsin Card Sorting Test (WCST) categories' achieved was the only measure on which psychotic patients performed significantly worse compared to non-psychotic patients. Differences among patient groups were not explained by illness severity measures. The duration of illness was related to slowness in psychomotor speed tasks. Verbal memory deficits may be related to serum lithium levels and age of onset of disease. Conclusions: Deficits in cognitive flexibility may be a candidate for being a trait marker of psychotic features among bipolar patients. However, verbal fluency, psychomotor speed and sustained attention deficits may be candidates for vulnerability indicators of bipolar disorder in general.en_US
dc.identifier.doi10.1111/j.1399-5618.2007.00469.xen_US
dc.identifier.endpage477en_US
dc.identifier.issn1398-5647
dc.identifier.issue5en_US
dc.identifier.pmid17680917en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage468en_US
dc.identifier.urihttps://doi.org/10.1111/j.1399-5618.2007.00469.x
dc.identifier.urihttps://hdl.handle.net/11454/39401
dc.identifier.volume9en_US
dc.identifier.wosWOS:000248590500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofBipolar Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbipolar disorderen_US
dc.subjectcognitionen_US
dc.subjectexecutive functionen_US
dc.subjectmaniaen_US
dc.subjectmemoryen_US
dc.subjectpsychotic symptomsen_US
dc.subjectsustained attentionen_US
dc.titleThe effect of previous psychotic mood episodes on cognitive impairment in euthymic bipolar patientsen_US
dc.typeArticleen_US

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