Isolation of resveratrol from peanut sprouts, radioiodination and investigation of its bioactivity on neuroblastoma cell lines

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dc.contributor.authorKaratay, Kadriye Busra
dc.contributor.authorKilcar, AyferYurt
dc.contributor.authorGuldu, Ozge Kozgus
dc.contributor.authorMedine, Emin Ilker
dc.contributor.authorMuftuler, Fazilet Zumrut Biber
dc.date.accessioned2020-12-01T12:01:11Z
dc.date.available2020-12-01T12:01:11Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractRecently, natural antioxidant substances have been purified in a significant increasing incline from different plants for diagnosis and treatment options. in the current study, Resveratrol (RES) was isolated and radioiodinated with iodine-131 ([I-131]iodo-RES). Cell culture studies were conducted on neuroblastoma cells (SY-SH5Y and SK-N-AS) to investigate the bioavailability of [I-131]iodo-RES. the radioiodination yield of RES was 98.81 +/- 0.37% (n = 6). Uptake values up to 25% were observed notably on SK-N-AS cells until 24 h. Briefly; the current study will contribute to the development of novel radiolabeled plant origin agents for the imaging of neuroblastoma cells.en_US
dc.description.sponsorshipEge University Scientific Research ProjectsEge University; Ege University/TURKEYEge University [FYL-2018-20081]en_US
dc.description.sponsorshipPresent study was supported by Ege University Scientific Research Projects, Ege University/TURKEY (Project Number: FYL-2018-20081). Authors thank to Mr. Resat YILDIZ for sending the seeds from "Osmaniye Oil Seeds Research Institute", Osmaniye/TURKEY. Also, authors thank to Dr. Volkan TEKIN and Msc. Cansu KAYAS for their technical help and thank to Mr. Ali Rza GULMEZ for support in growing peanut sprouts.en_US
dc.identifier.doi10.1007/s10967-020-07222-5
dc.identifier.endpage84en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85085561167en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-020-07222-5
dc.identifier.urihttps://hdl.handle.net/11454/62339
dc.identifier.volume325en_US
dc.identifier.wosWOS:000536433500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeanut sproutsen_US
dc.subjectResveratrolen_US
dc.subjectIodine-131en_US
dc.subjectRadioiodinationen_US
dc.subjectHuman neuroblastoma cell linesen_US
dc.titleIsolation of resveratrol from peanut sprouts, radioiodination and investigation of its bioactivity on neuroblastoma cell linesen_US
dc.typeArticleen_US

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