THE TOTAL ANTIOXIDANT CAPACITY MAY NOT BE RELATED TO BILIRUBIN AND URIC ACID LEVEL IN PATIENTS WITH BETA THALASSEMIA
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Iron burden resulting from ineffective erythropoiesisand multiple transfusions can cause oxidative stress in patientswith ß-thalassemia. Here we aimed to examine the total antioxidant and oxidant capacity (TAC and TOC) along with its relationto endogenous antioxidants (bilirubin and uric acid) in patientswith ß-thalassemia.Material and Method: Forty-five patients with transfusion-dependent (TDT) (n=30) and non-transfusion-dependent (NTDT)(n=15) ß-thalassemia and 20 healthy subjects were enrolled inthe study. Analyses were done using Total Antioxidant Status(TAS) and Total Oxidant Status (TOS) kits.Results: The TAC level of the patients was significantly increasedcompared to healthy subjects (2.75 vs. 2.10 mmol/L; p=0.01).The total bilirubin level was significantly elevated in NTDT patients compared to TDT patients (5.7±3.3 vs.1.9±1.4; p<0.001).No significant relationship between endogenous antioxidantsand total antioxidant capacity of patients was detected (p=0.20)Conclusion: The total antioxidant capacity of patients withß-thalassemia might not be directly related to endogenous anti-oxidative status.
Açıklama
Anahtar Kelimeler
Kaynak
İstanbul Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
83
Sayı
4
