The influence of the speed of food intake on multichannel impedance in patients with gastro-oesophageal reflux disease

Basit Öğe Kaydı
dc.contributor.authorBor, Serhat
dc.contributor.authorBayrakci, Berna
dc.contributor.authorErdogan, Askin
dc.contributor.authorYildirim, Esra
dc.contributor.authorVardar, Rukiye
dc.date.accessioned2019-10-27T22:08:10Z
dc.date.available2019-10-27T22:08:10Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: There is a general belief that gastro-oesophageal reflux increases after meals and especially following a rapid intake. Objective: To evaluate the impact of rapid vs. slow food intake on gastro-oesophageal reflux disease (GORD) patients. Materials and methods: Forty-six GORD patients with heartburn and / or acid regurgitation once a week or more often common were included in this study. Participants were asked to eat the same standard meal within either 5 or 30 minutes under observation in a random order on 2 consecutive days. A total of 28 hours of recording were obtained by intraoesophageal impedance pH and number of liquid and mixed reflux episodes within 3 hours of the slow- and fast-eating postprandial periods were calculated. Results: While all patients defined GORD symptoms, 10 (21.7%) had pathological 24-h intraoesophageal impedance measurement, 15 (32.6%) had pathological DeMeester and 21.7% had erosive oesophagitis. No difference has been shown according to the eating speed when all reflux episodes were taken together (754 vs. 733). Speed of food intake also did not have an impact on patients with normal vs. pathological 24-h intraoesophageal impedance or erosive vs. non-erosive. During the first postprandial hour, approximately half of the reflux events were non-acid, compared to 34.2% during the second hour and 26.8% during the third hour (p < 0.001). The number of acid reflux episodes was significantly higher than non-acid reflux especially during the second and third hours and in total for 3 hours. Conclusions: This first study addressing the effect of eating speed on reflux episodes in GORD patients did not support the general belief that reflux increases following fast eating. Acid and non-acid reflux were similar at the first postprandial hour, then acid reflux episodes were predominantly higher, which implicate the importance of acid pockets.en_US
dc.description.sponsorshipEge reflux study group [08.12.2009/09-5.1/3]en_US
dc.description.sponsorshipThis study was supported by Ege reflux study group, grant number: 08.12.2009/09-5.1/3.en_US
dc.identifier.doi10.1177/2050640613500266en_US
dc.identifier.endpage350en_US
dc.identifier.issn2050-6406
dc.identifier.issn2050-6414
dc.identifier.issue5en_US
dc.identifier.pmid24917982en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage346en_US
dc.identifier.urihttps://doi.org/10.1177/2050640613500266
dc.identifier.urihttps://hdl.handle.net/11454/49139
dc.identifier.volume1en_US
dc.identifier.wosWOS:000209200300006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofUnited European Gastroenterology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEatingen_US
dc.subjectfood habitsen_US
dc.subjectgastro-oesophageal refluxen_US
dc.subjectMIIen_US
dc.subjectoesophageal pH monitoringen_US
dc.subjectproton-pump inhibitorsen_US
dc.titleThe influence of the speed of food intake on multichannel impedance in patients with gastro-oesophageal reflux diseaseen_US
dc.typeArticleen_US

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