Antibodies to DNA repair proteins in headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) patients

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dc.contributor.authorErdag, Ece
dc.contributor.authorCelebisoy, Nese
dc.contributor.authorYuceyar, Ayse Nur
dc.contributor.authorKurtuncu, Murat
dc.contributor.authorVural, Burcak
dc.contributor.authorTuzun, Erdem
dc.date.accessioned2019-10-27T23:00:04Z
dc.date.available2019-10-27T23:00:04Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractAutoimmune mechanisms have been implicated in the pathogenesis of headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL). Pooled sera of five HaNDL patients and 30 controls (10 multiple sclerosis patients, 10 migraine patients, 10 healthy controls) were screened by protein macroarray. All sera were also individually subjected to immunoprecipitation with neuroblastoma cells and the bound antigens were identified by mass spectrometry. Antibodies to three DNA repair proteins (mitogen-activated protein kinase-4, DNA-dependent protein kinase catalytic subunit, DNA excision repair protein ERCC-6) were identified by both macroarray and immunoprecipitation methods in 3/5 HaNDL sera, but in none of the controls. The presence of DNA repair protein antibodies indicates DNA damage and provides further support for the inflammatory etiology of HaNDL.en_US
dc.identifier.doi10.1007/s13760-014-0334-7en_US
dc.identifier.endpage140en_US
dc.identifier.issn0300-9009
dc.identifier.issn2240-2993
dc.identifier.issue2en_US
dc.identifier.pmid25070837en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-014-0334-7
dc.identifier.urihttps://hdl.handle.net/11454/51937
dc.identifier.volume115en_US
dc.identifier.wosWOS:000354723700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHaNDLen_US
dc.subjectDNA repairen_US
dc.subjectAntibodyen_US
dc.subjectProtein macroarrayen_US
dc.subjectImmunoprecipitationen_US
dc.titleAntibodies to DNA repair proteins in headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) patientsen_US
dc.typeArticleen_US

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