In Silico Approach to Molecular Profiling of the Transition from Ovarian Epithelial Cells to Low-Grade Serous Ovarian Tumors for Targeted Therapeutic Insights

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dc.authoridLeblebici, Asım/0000-0002-5197-6631
dc.authoridBasbinar, Yasemin/0000-0001-9439-2217
dc.authoridArayici, Mehmet Emin/0000-0002-0492-5129
dc.authoridIsik, Zerrin/0000-0003-1779-1681
dc.contributor.authorLeblebici, Asim
dc.contributor.authorSancar, Ceren
dc.contributor.authorTercan, Bahar
dc.contributor.authorIsik, Zerrin
dc.contributor.authorArayici, Mehmet Emin
dc.contributor.authorEllidokuz, Ender Berat
dc.contributor.authorBasbinar, Yasemin
dc.date.accessioned2024-08-31T07:49:38Z
dc.date.available2024-08-31T07:49:38Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThis paper aims to elucidate the differentially coexpressed genes, their potential mechanisms, and possible drug targets in low-grade invasive serous ovarian carcinoma (LGSC) in terms of the biologic continuity of normal, borderline, and malignant LGSC. We performed a bioinformatics analysis, integrating datasets generated using the GPL570 platform from different studies from the GEO database to identify changes in this transition, gene expression, drug targets, and their relationships with tumor microenvironmental characteristics. In the transition from ovarian epithelial cells to the serous borderline, the FGFR3 gene in the Estrogen Response Late pathway, the ITGB2 gene in the Cell Adhesion Molecule, the CD74 gene in the Regulation of Cell Migration, and the IGF1 gene in the Xenobiotic Metabolism pathway were upregulated in the transition from borderline to LGSC. The ERBB4 gene in Proteoglycan in Cancer, the AR gene in Pathways in Cancer and Estrogen Response Early pathways, were upregulated in the transition from ovarian epithelial cells to LGSC. In addition, SPP1 and ITGB2 genes were correlated with macrophage infiltration in the LGSC group. This research provides a valuable framework for the development of personalized therapeutic approaches in the context of LGSC, with the aim of improving patient outcomes and quality of life. Furthermore, the main goal of the current study is a preliminary study designed to generate in silico inferences, and it is also important to note that subsequent in vitro and in vivo studies will be necessary to confirm the results before considering these results as fully reliable.en_US
dc.description.sponsorshipCouncil of Higher Education [2021.KB.SAG.060]; TUBITAK (Scientific and Technological Research Council of Turkiye) [2211/A]; Dokuz Eylul University Scientific Research Projects Coordination Unit; NCI grant, Cancer Target Discovery and Development Consortium [2214/A]; [U01 CA282109]; [100/2000 YOK]en_US
dc.description.sponsorshipA.L. was supported by the 100/2000 YOK (Council of Higher Education) Ph.D. Scholarship Program and TUBITAK (The Scientific and Technological Research Council of Tuerkiye) 2211/A & 2214/A National Ph.D. Scholarship Program. Dokuz Eylul University Scientific Research Projects Coordination Unit supported this research with project number 2021.KB.SAG.060. B.T. has been supported by NCI grant A Patient-Centric Approach to Advance Functional Precision Oncology (U01 CA282109) grant as part of the Cancer Target Discovery and Development Consortium. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to thank Sila Ovgu Korkut-Uysal for her suggestions and contributions.en_US
dc.identifier.doi10.3390/cimb46030117
dc.identifier.endpage1798en_US
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue3en_US
dc.identifier.pmid38534733en_US
dc.identifier.scopus2-s2.0-85188740163en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1777en_US
dc.identifier.urihttps://doi.org/10.3390/cimb46030117
dc.identifier.urihttps://hdl.handle.net/11454/104921
dc.identifier.volume46en_US
dc.identifier.wosWOS:001191550200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCurrent Issues In Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectLow-Grade Serous Ovarian Canceren_US
dc.subjectBorderlineen_US
dc.subjectGene Coexpression Networken_US
dc.subjectIn Silico Integrative Data Analysisen_US
dc.titleIn Silico Approach to Molecular Profiling of the Transition from Ovarian Epithelial Cells to Low-Grade Serous Ovarian Tumors for Targeted Therapeutic Insightsen_US
dc.typeArticleen_US

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