Calcineurin inhibitor-based and free regimens have distinct gene expression patterns in subclinical graft fibrosis

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dc.contributor.authorToz, Huseyin
dc.contributor.authorSen, Sait
dc.contributor.authorCelik, Handan Ak
dc.contributor.authorYilmaz, Mumtaz
dc.contributor.authorHur, Ender
dc.contributor.authorHoscoskun, Cuneyt
dc.contributor.authorOzkahya, Mehmet
dc.contributor.authorAydin, Hikmet Hakan
dc.date.accessioned2019-10-27T21:24:28Z
dc.date.available2019-10-27T21:24:28Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Chronic nephrotoxic effects of calcineurin inhibitors may be responsible for late allograft dysfunction and reduced allograft half-life. Mammalian target of rapamycin inhibitors (mTOR-i's), a newer class of immunosuppressant, do not have the chronic nephrotoxic effects shown with calcineurin inhibitors (CNI). Whether these drug classes have distinct features at the molecular level is not clear. Material/Methods: Difference in gene expression profiles of kidney graft protocol biopsies from patients treated with CNI or mTOR-i's were investigated. Biopsies from patients using CNI (n=4) and mTOR-i-based treatments (n=4) were analyzed. The control group consisted of 5 biopsies obtained at the time of implantation (zero hour). Microarray hybridization was performed using the Affymetrix (R) GeneChip U133 plus 2.0 Array. Results: In the CNI and mTOR-i groups, 64 up-regulated and 119 down-regulated genes were found compared to control subjects. A total of 29 genes in the CNI group and 101 genes in the mTOR-i group were up-regulated compared to each other. Conclusions: Despite similar clinical courses and histopathological appearances, different treatment strategies cause different gene expression profiles in kidney transplantation.en_US
dc.identifier.endpage87en_US
dc.identifier.issn1425-9524
dc.identifier.issue2en_US
dc.identifier.pmid21716190en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://hdl.handle.net/11454/44547
dc.identifier.volume16en_US
dc.identifier.wosWOS:000293321500012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Scientific Literature, Incen_US
dc.relation.ispartofAnnals of Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectkidney transplantationen_US
dc.subjectcalcineurinen_US
dc.subjectmTOR-Ien_US
dc.subjectmicroarray analysisen_US
dc.titleCalcineurin inhibitor-based and free regimens have distinct gene expression patterns in subclinical graft fibrosisen_US
dc.typeArticleen_US

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