A preliminary study on the use of ultrasound for obtaining pulsatile release [Pulsatil salım elde edilmesi amacıyla ultrason kullanımı üzerine bir ön çalışma]

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dc.contributor.authorKomeslİ Y.
dc.contributor.authorÇetİn E.Ö.
dc.contributor.authorKırılmaz L.
dc.contributor.authorGündoğdu E.
dc.date.accessioned2019-10-26T21:28:52Z
dc.date.available2019-10-26T21:28:52Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, the controlled release tablet of diltiazem hydrochloride was developed. The controlled release tablets were prepared with ethyl cellulose by changing the ratio of diltiazem hydrochloride and the in vitro release studies were carried out by using an ultrasonic water bath. According to release results, a new equation was developed that can be used to estimate the release of drug as a function of time and drug content in the formulation. In addition, the effect of ultrasound on the release of diltiazem hydrochloride from controlled release dosage forms and relationships between release rate constants and drug contents were investigated. This study showed that the developed equation can successfully be used to estimate the effect of ultrasound on the release of drug from the formulations prepared with different concentrations of diltiazem hydrochloride. It was concluded that ultrasound has a very important effect on the release of drug and increases drug release obviously. © 2014, Marmara University. All rights reserved.en_US
dc.identifier.doi10.12991/mpj.2014187236
dc.identifier.endpage108en_US
dc.identifier.issn1309-0801
dc.identifier.issn1309-0801en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.12991/mpj.2014187236
dc.identifier.urihttps://hdl.handle.net/11454/17516
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofMarmara Pharmaceutical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectControlled releaseen_US
dc.subjectPulsatile releaseen_US
dc.subjectUltrasounden_US
dc.titleA preliminary study on the use of ultrasound for obtaining pulsatile release [Pulsatil salım elde edilmesi amacıyla ultrason kullanımı üzerine bir ön çalışma]en_US
dc.typeArticleen_US

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