A preliminary study on the use of ultrasound for obtaining pulsatile release [Pulsatil salım elde edilmesi amacıyla ultrason kullanımı üzerine bir ön çalışma]
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara University
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the controlled release tablet of diltiazem hydrochloride was developed. The controlled release tablets were prepared with ethyl cellulose by changing the ratio of diltiazem hydrochloride and the in vitro release studies were carried out by using an ultrasonic water bath. According to release results, a new equation was developed that can be used to estimate the release of drug as a function of time and drug content in the formulation. In addition, the effect of ultrasound on the release of diltiazem hydrochloride from controlled release dosage forms and relationships between release rate constants and drug contents were investigated. This study showed that the developed equation can successfully be used to estimate the effect of ultrasound on the release of drug from the formulations prepared with different concentrations of diltiazem hydrochloride. It was concluded that ultrasound has a very important effect on the release of drug and increases drug release obviously. © 2014, Marmara University. All rights reserved.
Açıklama
Anahtar Kelimeler
Controlled release, Pulsatile release, Ultrasound
Kaynak
Marmara Pharmaceutical Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
18
Sayı
3
