Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth

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dc.authorid0000-0002-3846-8368
dc.authorid0000-0001-7207-4955
dc.authorid0000-0002-1590-5801
dc.contributor.authorAlan, Murat
dc.contributor.authorSorsa, Timo
dc.contributor.authorMeric Kantar, Pinar
dc.contributor.authorRaisanen, Ismo T.
dc.contributor.authorGurlek, Onder
dc.contributor.authorKanmaz, Burcu
dc.contributor.authorBuduneli, Nurcan
dc.date.accessioned2025-03-20T13:19:55Z
dc.date.available2025-03-20T13:19:55Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjective: To investigate serum, placental levels of active-matrix metalloproteinase-8 (aMMP-8), myeloperoxidase (MPO) in preterm-birth with/without pre-eclampsia and term counterparts in relation with clinical periodontal parameters. Methods: Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full-term (FT), pre-term (PT) or pre-term complicated by pre-eclampsia (PTPE) deliveries. aMMP-8 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non-parametric tests. Results: PTBE group exhibited higher full-mouth probing depth and clinical attachment loss values than the other two groups (p < 0.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in the other groups (p < 0.05). Serum aMMP-8 and MPO concentrations were higher in PTPE group than in the other groups (p < 0.05). Placenta aMMP-8 level was higher in the control group than in the PTPE group (p < 0.05). There was no significant difference between the groups in the placenta MPO levels (p > 0.05). Conclusions: Within the limits of this cross-sectional study, it may be suggested that serum aMMP-8 and MPO concentrations together with placenta aMMP-8 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.
dc.identifier.citationAlan, M., Sorsa, T., Kantar, P. M., Raisanen, I. T., Gurlek, O., Kanmaz, B., & Buduneli, N. (2024). Active-matrix metalloproteinase-8, myeloperoxidase in relation with periodontics, preterm birth. Oral Diseases.
dc.identifier.doi10.1111/odi.15202
dc.identifier.endpage9
dc.identifier.issn1354523X
dc.identifier.issueNov
dc.identifier.pmid39543825
dc.identifier.scopus2-s2.0-85209091382
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1111/odi.15202
dc.identifier.urihttps://hdl.handle.net/11454/116856
dc.identifier.wosWOS:001358312600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMeric Kantar, Pinar
dc.institutionauthorGurlek, Onder
dc.institutionauthorBuduneli, Nurcan
dc.institutionauthorid0000-0002-3846-8368
dc.institutionauthorid0000-0001-7207-4955
dc.institutionauthorid0000-0002-1590-5801
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofOral Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMMP-8
dc.subjectMPO
dc.subjectperiodontal disease
dc.subjectplacenta
dc.subjectpreeclampsia
dc.subjectpreterm birth
dc.titleActive-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth
dc.typeArticle

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