The effects of zoledronic acid on neointimal hyperplasia: A rabbit carotid anastomosis model [Neointimal hiperplazi üzerine zoledronik asidin etkileri: Tavşan karotis anastomoz modeli]

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dc.contributor.authorGüzeloglu M.
dc.contributor.authorGül M.
dc.contributor.authorReel B.
dc.contributor.authorYürekli I.
dc.contributor.authorAykut K.
dc.contributor.authorHazan E.
dc.date.accessioned2019-10-27T08:34:02Z
dc.date.available2019-10-27T08:34:02Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to investigate the effect of zoledronic acid (ZA), as a matrix metalloproteinase inhibitor, on neointimal hyperplasia in rabbit carotid anastomosis model. Methods: New Zealand male rabbits were divided into two groups as placebo and treatment groups in this experimental study. After anesthesia, the right carotid artery of each rabbit was end-to-end anastomosed with an 8/0 polypropylene suture. Left carotid artery was kept as control without any operation. Placebo group (n=6) received phosphate buffered saline (PBS) (0.5mL/kg/day/s.c.) for 28 days postoperatively, whereas ZA group (n=6) received ZA (100 µg/kg/day/s.c.) for the same period. After sacrification, the anastomosed and control arteries were isolated. Morphometric and immunohistochemical examinations were performed. Statistical analyses of morphometric and immunohistochemical data were performed using two-way ANOVA and Chi-square test respectively. Results: In PBS group, vascular injury in the anastomosed artery significantly increased the intimal area (anastomosed: 112.51±61.18 µm 2*1000 vs. control: 22.62±4.26µm 2*1000, p<0.01) and intima/media index (anastomosed: 0.347±0.29 vs. control: 0.075±0.01, p<0.05) compared to control artery. ZA significantly reduced the intimal area (39.29±18.21 µm 2*1000, p<0.01) and intima/media index (0.112±0.07, p<0.05) compared to PBS group. Additionally, ?-smooth muscle actin immunopositivity was found significantly decreased in anastomosed arteries from ZA group (ZA: 2.33±0.52 vs. PBS: 3.50±0.5, p<0.05). Moreover, intensive gelatinase (MMP-2 and MMP-9) immunoreactivities were clearly seen in anastomosed arteries compared to control arteries from PBS group. ZA apparently decreased immunopositivities for gelatinases in anastomosed arteries. Conclusion: ZA might be a promising agent for prevention of neointimal hyperplasia, which is the most significant cause of graft failures in late postoperative period. © 2011 by AVES Yayi{dotless}nci{dotless}li{dotless}k Ltd.en_US
dc.identifier.doi10.5152/akd.2011.026en_US
dc.identifier.endpage100en_US
dc.identifier.issn1302-8723
dc.identifier.issue2en_US
dc.identifier.pmid21285021en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2011.026
dc.identifier.urihttps://hdl.handle.net/11454/26952
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMatrix metalloproteinases (MMPS)en_US
dc.subjectNeointimalen_US
dc.subjectRabbiten_US
dc.subjectZoledronic aciden_US
dc.titleThe effects of zoledronic acid on neointimal hyperplasia: A rabbit carotid anastomosis model [Neointimal hiperplazi üzerine zoledronik asidin etkileri: Tavşan karotis anastomoz modeli]en_US
dc.typeArticleen_US

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