Association of Interleukin-6-174 G > C Promoter Polymorphism with Increased Risk of Type 2 Diabetes Mellitus Patients with Diabetic Nephropathy in Turkey

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dc.contributor.authorKaradeniz, Muammer
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorBerdeli, Afig
dc.contributor.authorYilmaz, Candeger
dc.date.accessioned2019-10-27T22:05:56Z
dc.date.available2019-10-27T22:05:56Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in type 2 DN and control subjects. Materials and Methods: The patients selected from the Department of Endocrinology and Metabolism Diseases included 43 type 2 diabetes mellitus patients without DN and 43 type 2 diabetes mellitus patients with DN and 340 healthy normal controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, and insulin and Il-6 gene polymorphism genetic analysis. Results: IL-6 -174 G>C genotype distribution was different between the control group and the type 2 diabetes mellitus patients (p=0.004). The higher frequency of the polymorphic G allele was also similar for the group with type 2 diabetes mellitus as for the control group. The frequency of the polymorphic G allele was 83.9% in diabetic patients with nephropathy versus 70.9% in those without nephropathy (p=0.039). Conclusion: We suggest that the -174 G>C polymorphism of the IL-6 gene is an independent risk factor for DN in Turkish type 2 diabetes mellitus patients.en_US
dc.identifier.doi10.1089/gtmb.2013.0357en_US
dc.identifier.endpage65en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue1en_US
dc.identifier.pmid24102240en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2013.0357
dc.identifier.urihttps://hdl.handle.net/11454/48653
dc.identifier.volume18en_US
dc.identifier.wosWOS:000335820100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation of Interleukin-6-174 G > C Promoter Polymorphism with Increased Risk of Type 2 Diabetes Mellitus Patients with Diabetic Nephropathy in Turkeyen_US
dc.typeArticleen_US

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