In vitro evaluation of Tc-99m-sultamicillin for infection imaging

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dc.authoridRostami-Hodjegan, Amin/0000-0003-3917-844X
dc.authoridYurt, Fatma/0000-0002-9394-6908
dc.authorscopusid16686248800
dc.authorscopusid57200179167
dc.authorscopusid6602719646
dc.contributor.authorDurkan, Kubra
dc.contributor.authorTuncel, Ayca
dc.contributor.authorYurt, Fatma
dc.date.accessioned2023-01-12T19:49:40Z
dc.date.available2023-01-12T19:49:40Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractEarly detection of the site of infection non-invasively with radiolabeled molecules is important for the success of treatment. Technetium-99m labeled antibiotics have the potential to discriminate between bacterial infection and sterile inflammation. Sultamicillin is the tosylate salt of the double ester of sulbactam plus ampicillin. In this study, sultamicillin was labeled with Tc-99m according to the stannous chloride method. Quality control studies of radiolabeled sultamicillin were performed by radiochromatographic methods. In vitro binding assays were performed in live and heat-killed gram-positive Staphylococcus aureus and gram-negative Escherichia coli strains. The radiolabeling yield of Tc-99m-sultamicillin was determined as 97.8% +/- 3.1% (n = 5). The maximum bacterial uptake of Tc-99m-sultamicillin was 80.7% +/- 11.00% at 4 h for living S. aureus and 93.2% +/- 4.40% at 2 h for E. coli. Bacterial uptake study results show that sultamicillin has the potential to be a nuclear imaging agent, especially in infections caused by gram-negative E. coli and gram-positive S. aureus.en_US
dc.description.sponsorshipEge University [17 NBE 007]en_US
dc.description.sponsorshipEge University, Grant/Award Number: 17 NBE 007en_US
dc.identifier.doi10.1002/bdd.2281
dc.identifier.endpage293en_US
dc.identifier.issn0142-2782
dc.identifier.issn1099-081X
dc.identifier.issue6en_US
dc.identifier.pmid33904176en_US
dc.identifier.scopus2-s2.0-85105253370en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1002/bdd.2281
dc.identifier.urihttps://hdl.handle.net/11454/75877
dc.identifier.volume42en_US
dc.identifier.wosWOS:000647604500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBiopharmaceutics & Drug Dispositionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbacterial bindingen_US
dc.subjectin vitroen_US
dc.subjectinfectionen_US
dc.subjectsultamicillinen_US
dc.subjecttechnetium&#8208en_US
dc.subject99men_US
dc.subjectStaphylococcus-Aureusen_US
dc.subjectBiological Evaluationen_US
dc.subjectQuality-Controlen_US
dc.subjectBiodistributionen_US
dc.subjectInflammationen_US
dc.subjectRadiopharmaceuticalsen_US
dc.subjectAntibioticsen_US
dc.subjectBacteriaen_US
dc.subjectAgenten_US
dc.titleIn vitro evaluation of Tc-99m-sultamicillin for infection imagingen_US
dc.typeArticleen_US

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