IN VITRO ACTIVITY OF LINEZOLID/ERTAPENEM COMBINATION IN RESISTANT GRAM-POSITIVE BACTERIA

Basit Öğe Kaydı
dc.contributor.authorErac, Bayri
dc.contributor.authorTasli, Hueseyin
dc.contributor.authorErmertcan, Safak
dc.contributor.authorCilli, Feriha
dc.contributor.authorLimoncu, Mine Hosgoer
dc.date.accessioned2019-10-27T20:21:23Z
dc.date.available2019-10-27T20:21:23Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractThe increasing prevalence of vancomycin-resistant enterococcus and methicillin-resistant staphylococcus infections has become a major therapeutic challenge and alternative therapy options are under consideration. In the present study, we aimed to evaluate the in vitro antibacterial activity of linezolid combined with ertapenem against two vancomycin-resistant Enterococcus faecium (VREF), two methicillin-resistant Staphylococcus aureus (MRSA) and two methicillin-resistant Staphylococcus epidermidis (MRSE) strains isolated from clinical specimens. In vitro activity of linezolid/ertapenem combination at 112 x MIC (minimal Inhibitory Concentration), 1 x MIC and 4 x MIC concentrations for each of the isolates was determined by time-kill curve method. At 1 x MIC and 4 x MIC concentrations, additive effect was detected for MRSA (at 6 and 24 h) and VREF (at 6 h) strains. Synergism was observed between two antibiotics at 4 x MIC concentration against one of the MRSE strains at 6(th) hour. Additive effect was determined at 6(th) and 24(th) hours in this strain at 1 x MIC concentration. No synergism was present in the other MRSE strain but additive interaction was detected at 6 h (1/2 x MIC) and 24 h (1 x MIC). Although these results support the use of linezolid/ertapenem combination in infections caused by resistant gram-positive strains, further in vitro and in vivo studies are necessary.en_US
dc.identifier.endpage51en_US
dc.identifier.issn0374-9096
dc.identifier.issue1en_US
dc.identifier.pmid19334379en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://hdl.handle.net/11454/41755
dc.identifier.volume43en_US
dc.identifier.wosWOS:000263117000006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethicillin-resistant staphylococcien_US
dc.subjectvancomycin-resistant enterococcien_US
dc.subjectlinezoliden_US
dc.subjectertapenemen_US
dc.subjecttime-kill curveen_US
dc.titleIN VITRO ACTIVITY OF LINEZOLID/ERTAPENEM COMBINATION IN RESISTANT GRAM-POSITIVE BACTERIAen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu