Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study

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dc.authoridÖzenci, Volkan/0000-0002-8069-4027
dc.authoridKaratas, Mustafa/0000-0002-2464-0593
dc.authoridYasar-Duman, Melike/0000-0001-8913-2314
dc.authoridAydemir, Sabire Sohret/0000-0001-8354-9100
dc.authorscopusid57226767083
dc.authorscopusid57194681921
dc.authorscopusid6602210366
dc.authorscopusid6507459615
dc.authorscopusid8905840200
dc.authorscopusid6701793279
dc.authorwosidÖzenci, Volkan/H-3116-2019
dc.authorwosidKaratas, Mustafa/GQH-0977-2022
dc.contributor.authorKaratas, Mustafa
dc.contributor.authorYasar-Duman, Melike
dc.contributor.authorTunger, Alper
dc.contributor.authorCilli, Feriha
dc.contributor.authorAydemir, Sohret
dc.contributor.authorOzenci, Volkan
dc.date.accessioned2023-01-12T20:04:44Z
dc.date.available2023-01-12T20:04:44Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era. Methods Microbiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data. Results In total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001). Conclusion Due to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher.en_US
dc.description.sponsorshipKarolinska Instituteen_US
dc.description.sponsorshipOpen access funding provided by Karolinska Institute. The author(s) received no specific funding for this work.en_US
dc.identifier.doi10.1186/s12941-021-00454-7
dc.identifier.issn1476-0711
dc.identifier.issue1en_US
dc.identifier.pmid34353332en_US
dc.identifier.scopus2-s2.0-85112643790en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s12941-021-00454-7
dc.identifier.urihttps://hdl.handle.net/11454/77818
dc.identifier.volume20en_US
dc.identifier.wosWOS:000681736800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofAnnals of Clinical Microbiology and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSecondary bacterial infectionsen_US
dc.subjectCo-infectionsen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectPredictorsen_US
dc.subjectIncreaseen_US
dc.subjectOutbreaken_US
dc.titleSecondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center studyen_US
dc.typeArticleen_US

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