Interleukin (IL)-12, IL-2, and IL-6 gene polymorphisms in Takayasu's arteritis from Turkey

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dc.contributor.authorSaruhan-Direskeneli, G.
dc.contributor.authorBicakcigil, M.
dc.contributor.authorYilmaz, V.
dc.contributor.authorKamali, S.
dc.contributor.authorAksu, K.
dc.contributor.authorFresko, I.
dc.contributor.authorAkkoc, N.
dc.contributor.authorKiraz, S.
dc.contributor.authorOzer, H. T. E.
dc.contributor.authorTunc, E.
dc.contributor.authorYucel, E.
dc.contributor.authorKaraarslan, Y.
dc.contributor.authorUyar, F. A.
dc.contributor.authorDoganavsargil, E.
dc.contributor.authorInanc, M.
dc.contributor.authorDireskeneli, H.
dc.date.accessioned2019-10-27T19:17:29Z
dc.date.available2019-10-27T19:17:29Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractTakayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Genetic polymorphisms of cytokines are screened as susceptibility factors for TA in Turkey. A total of 94 patients with TA were investigated for the genetic polymorphisms of the interleukin genes IL12, IL2,and IL6 and were compared with 108 healthy control subjects using polymerase chain reaction-sequence-specific primer method. The frequencies of IL12B 1188 C allele (p = 0.03, OR = 1.7) and CC genotype (p = 0.007, OR = 3.7) were both higher in TA patients than in control subjects. TT genotype at IL2-330 (p = 0.006, OR = 2.4) and GG genotype at IL6-174 (p = 0.04, OR = 1.9) were more frequent in TA patients. Lower prevalence of GT genotype at IL2-330 (P = 0,005, OR = 0.4), CG genotype at IL6-174 (p = 0.001, OR = 0.4), and AG genotypes at IL6-598 (p = 0.01, OR = 0.4) were also detected. The polymorphism of IL-12 as well as IL-6 and IL-2 genes may contribute to susceptibility and pathogenesis of TA by altering cytokine production and inducing inflammation. (c) American Society for Histocompatibility and Immunogenetics, 2006. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.humimm.2006.06.003en_US
dc.identifier.endpage740en_US
dc.identifier.issn0198-8859
dc.identifier.issn1879-1166
dc.identifier.issue9en_US
dc.identifier.pmid17002904en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage735en_US
dc.identifier.urihttps://doi.org/10.1016/j.humimm.2006.06.003
dc.identifier.urihttps://hdl.handle.net/11454/38392
dc.identifier.volume67en_US
dc.identifier.wosWOS:000241168200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofHuman Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTakayasuen_US
dc.subjectIL6en_US
dc.subjectIL12en_US
dc.subjectIL2en_US
dc.subjectpolymorphismen_US
dc.titleInterleukin (IL)-12, IL-2, and IL-6 gene polymorphisms in Takayasu's arteritis from Turkeyen_US
dc.typeArticleen_US

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