Effect of Mean Platelet Volume on Postintervention Coronary Blood Flow in Patients with Chronic Stable Angina Pectoris

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dc.contributor.authorDuygu, Hamza
dc.contributor.authorTurkoglu, Cuneyt
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorTurk, Ugur
dc.date.accessioned2019-10-27T19:55:09Z
dc.date.available2019-10-27T19:55:09Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives. In our study we sought to determine whether mean platelet volume (MPV), measured on admission, could be used in determining decreased coronary blood flow (CBF) in stable coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). Background. Platelets play a crucial role in the pathophysiology of CAD. MPV reflects platelet function and activity. There are no reports regarding the effect of MPV on CBF in patients with stable CAD undergoing PCI. Methods. A total of 66 consecutive patients (mean age: 58 +/- 5 years, 74% male) with the diagnosis of stable CAD who were hospitalized for PCI were prospectively enrolled in our study. Coronary flow rates of all subjects were documented by corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) for each major coronary artery before and after PCI. Blood samples for MPV estimation, platelet count and other laboratory data obtained on admission were measured on the day of the scheduled PCI. Patients were divided into two groups according to MPV levels measured on admission: 1) high MPV group and 2) normal MPV group. Results. A final TIMI 3 flow was achieved in all patients with no complications. Procedural characteristics of PCI, except left anterior descending artery intervention, were similar in the two groups. Patients with high MPV had significantly higher CTFC than those with a normal MPV (24 +/- 3 vs. 17 +/- 5; p = 0.001). The MPV correlated strongly with post-PCI CTFC (R = 0.625; p = 0.0001). Multiple logistic regression analysis showed that only MPV was an independent predictor of post-PCI CTFC after adjustment for baseline characteristics (OR 1.9, 95% CI 1.2-2.3; p = 0.001). Conclusions. MPV may be considered a useful hematological marker, allowing for early and easy identification of patients with stable CAD who are at a higher risk of post-PCI low-reflow.en_US
dc.identifier.endpage124en_US
dc.identifier.issn1042-3931
dc.identifier.issn1557-2501
dc.identifier.issue3en_US
dc.identifier.pmid18316827en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://hdl.handle.net/11454/40638
dc.identifier.volume20en_US
dc.identifier.wosWOS:000207738600007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherH M P Communicationsen_US
dc.relation.ispartofJournal of Invasive Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoronary flowen_US
dc.subjectstable coronary artery diseaseen_US
dc.subjectplatelet functionen_US
dc.titleEffect of Mean Platelet Volume on Postintervention Coronary Blood Flow in Patients with Chronic Stable Angina Pectorisen_US
dc.typeArticleen_US

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