The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes

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dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorAcara, Ahmet Cagdas
dc.contributor.authorErbas, Oytun
dc.contributor.authorOltulu, Fatih
dc.contributor.authorYavasoglu, Nefise Ulku Karabay
dc.contributor.authorUysal, Aysegul
dc.contributor.authorYavasoglu, Altug
dc.date.accessioned2019-10-27T11:10:12Z
dc.date.available2019-10-27T11:10:12Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractDiabetes is a multisystem disorder and its effects are observed on the reproductive system. One of the main causes of testicular tissue damage is diabetes-induced overproduction of reactive oxygen species and glycated end products. The main objectives of this study were to investigate the possible effects of agomelatine (AG) and gallic acid (GA) in suppressing oxidative stress in Type I diabetes induced testicular damage. A total of 28 adult male rats were included in the study. Diabetes was induced by intraperitoneal injection of streptozocin (STZ, 55 mg/kg) to 21 rats, which were then randomly assigned to 3 groups; 1 mL saline solution was given to the diabetes + saline group by oral gavage, 20 mg/kg/day oral AG was given to the diabetes + AG group, and 20 mg/kg/day oral GA was given to the diabetes + GA group for 4 weeks. Tumor necrosis factor alpha (TNF alpha), nitric oxide synthase 2 (NOS2), fibronectin and vascular endothelial growth factor (VEGF) were used for the investigation of inflammation, fibrosis and vascular structures. The terminal-deoxynucleoitidyl-transferase mediated nick end-labeling assay (TUNEL) was used to detect apoptosis. Testicular tissue total antioxidant capacity values were tested by biochemical analysis. AG treatment showed an improvement on biochemical parameters and histopathological appearance on the rat testes. GA showed dose-related regenerative effects on biochemical parameters. Histologically, a minimal healing effect was determined on the testes damage. In conclusion, it was observed that AG is a potentially beneficial agent for reducing testicular damage by decreasing oxidative stress level. However, GA was seen to have a poor therapeutic effect. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.biopha.2016.12.102en_US
dc.identifier.endpage246en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid28061407en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2016.12.102
dc.identifier.urihttps://hdl.handle.net/11454/32370
dc.identifier.volume87en_US
dc.identifier.wosWOS:000395525600027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectStreptozotocinen_US
dc.subjectAgomelatinen_US
dc.subjectGallic aciden_US
dc.subjectTestesen_US
dc.subjectAntioxidanten_US
dc.titleThe antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testesen_US
dc.typeArticleen_US

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