The Role of Educational Attainment and Brain Morphology in Major Depressive Disorder: Findings From the ENIGMA Major Depressive Disorder Consortium

Basit Öğe Kaydı
dc.authoridSingh, Aditya/0000-0002-0539-7129
dc.authoridThompson, Paul/0000-0002-4720-8867
dc.authoridSchmaal, Lianne/0000-0001-9822-048X
dc.authoridStein, Dan/0000-0001-7218-7810
dc.authoridHermesdorf, Marco/0000-0003-3541-7212
dc.authoridKrug, Axel/0000-0002-0564-2497
dc.authoridMeinert, Susanne/0000-0003-2177-7161
dc.authorwosidThompson, Paul/C-4194-2018
dc.authorwosidWhittle, Sarah/I-2200-2014
dc.authorwosidStein, Dan/A-1752-2008
dc.authorwosidUYAR DEMIR, ASLIHAN/HHS-8987-2022
dc.contributor.authorWhittle, Sarah
dc.contributor.authorRakesh, Divyangana
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorVeltman, Dick J.
dc.contributor.authorThompson, Paul M.
dc.contributor.authorSingh, Aditya
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2024-08-25T18:51:54Z
dc.date.available2024-08-25T18:51:54Z
dc.date.issued2022
dc.departmentEge Üniversitesien_US
dc.description.abstractBrain structural abnormalities and low educational attainment are consistently associated with major depressive disorder (MDD), yet there has been little research investigating the complex interaction of these factors. Brain structural alterations may represent a vulnerability or differential susceptibility marker, and in the context of low educational attainment, predict MDD. We tested this moderation model in a large multisite sample of 1958 adults with MDD and 2921 controls (aged 18 to 86) from the ENIGMA MDD working group. Using generalized linear mixed models and within-sample split-half replication, we tested whether brain structure interacted with educational attainment to predict MDD status. Analyses revealed that cortical thickness in a number of occipital, parietal, and frontal regions significantly interacted with education to predict MDD. For the majority of regions, models suggested a differential susceptibility effect, whereby thicker cortex was more likely to predict MDD in individuals with low educational attainment, but less likely to predict MDD in individuals with high educational attainment. Findings suggest that greater thickness of brain regions subserving visuomotor and social-cognitive functions confers susceptibility to MDD, dependent on level of educational attainment. Longitudinal work, however, is ultimately needed to establish whether cortical thickness represents a preexisting susceptibility marker. General Scientific Summary Findings from this study provide support for a complex interplay of biological and environmental factors being important in predicting major depressive disorder. Findings suggest that alterations in brain structure may not predict depression in all individuals; rather, such alterations may only predict depression in the context of adverse environmental experiences. Conversely, these same alterations may protect against depression in the context of positive environmental experiences.en_US
dc.description.sponsorshipNational Institutes of Health [U54 EB020403, R01 MH116147, R01 MH117601]; NHMRC [1125504]; Melbourne Research Scholarship (MRS); NHMRC Career Development Fellowship [1140764]; University Medical Center Goettingen (UMG Startfoerderung); German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung [BMBF: 01 ZX 1507]; Generalitat de Catalunya [2017SGR1343]; Instituto Carlos III (Spanish Ministry of Health); European Regional Development Fund/European Social Fund Investing in your future; CIBERSAM [G21]; Deutsche Forschungsgemeinschaft (DFG) [GR1950/5-1, GR1950/10-1]; Gratama Foundation, the Netherlands [2012/35]; German Research Foundation (DFG) [FOR2107 KR 3822/7-2, FOR2107 KI 588/14-2, FOR2107 JA 1890/7-2]; National Institute of Mental Health [R01 085667]; Dunn Research Foundation; Pat Rutherford, Jr. Endowed Chair in Psychiatry; Italian Ministry of University and Scientific Research [RF-2011-02349921]; NHG Research Grant [SIG/15012]; Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403]; Ministry of Cultural Affairs; Social Ministry of the Federal State of Mecklenburg-West Pomerania; Siemens Healthineers, Erlangen, Germany; Federal State of Mecklenburg-West Pomerania; German Federal Ministry of Education and Research (BMBF) [FKZ-01ER0816, FKZ-01ER1506]; Phyllis and Jerome Lyle Rappaport Foundationen_US
dc.description.sponsorshipENIGMA MDD work is supported by National Institutes of Health Grants U54 EB020403 (Paul M. Thompson), R01 MH116147 (Paul M. Thompson), and R01 MH117601 (Lianne Schmaal). Sarah Whittle was supported by an NHMRC Career Development Fellowship (ID: 1125504), Divyangana Rakesh was supported by a Melbourne Research Scholarship (MRS). Lianne Schmaal was supported by an NHMRC Career Development Fellowship (1140764). AFFDIS cohort: this study was funded by the University Medical Center Goettingen (UMG Startfoerderung) and the research team is supported by German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung, BMBF: 01 ZX 1507, PreNeSt - e:Med). Barcelona cohort: Funded by Generalitat de Catalunya (2017SGR1343), several Grants from the Instituto Carlos III (Spanish Ministry of Health), the European Regional Development Fund/European Social Fund Investing in your future, and CIBERSAM (G21). CLING cohort: this study was partially supported by the Deutsche Forschungsgemeinschaft (DFG) via Grants to Oliver Gruber (GR1950/5-1 and GR1950/10-1). DIP-Groningen cohort: this study was supported by the Gratama Foundation, the Netherlands (2012/35 to NG). FOR2107-Marburg cohort: funded by the German Research Foundation (DFG, Grant FOR2107 KR 3822/7-2 to Axel Krug; FOR2107 KI 588/14-2 to Tilo Kircher and FOR2107 JA 1890/7-2). Houston cohorts: supported in part by National Institute of Mental Health Grant R01 085667 and the Dunn Research Foundation. Jair C. Soares is supported by the Pat Rutherford, Jr. Endowed Chair in Psychiatry. Milan Cohort: Funded by Italian Ministry of University and Scientific Research (RF-2011-02349921). Singapore Cohort: Funded by the NHG Research Grant (SIG/15012) awarded to Kang Sim. SHIP-trend cohorts: SHIP is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (ID: 01ZZ9603, 01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social Ministry of the Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint Grant from Siemens Healthineers, Erlangen, Germany, and the Federal State of Mecklenburg-West Pomerania. Stanford cohorts: this work was supported by National Institutes of Health Grant R37 MH101495. The BiDirect Study was supported by Grants from the German Federal Ministry of Education and Research (BMBF; Grants FKZ-01ER0816 and FKZ-01ER1506). Matthew D. Sacchet is partially supported by an Award funded by the Phyllis and Jerome Lyle Rappaport Foundation.en_US
dc.identifier.doi10.1037/abn0000738
dc.identifier.endpage673en_US
dc.identifier.issn2769-7541
dc.identifier.issn2769-755X
dc.identifier.issue6en_US
dc.identifier.pmid35653754en_US
dc.identifier.startpage664en_US
dc.identifier.urihttps://doi.org/10.1037/abn0000738
dc.identifier.urihttps://hdl.handle.net/11454/102757
dc.identifier.volume131en_US
dc.identifier.wosWOS:000969034600016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Psychological Assocen_US
dc.relation.ispartofJournal of Psychopathology and Clinical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectsocioeconomic statusen_US
dc.subjectdiathesis-stressen_US
dc.subjectdifferential susceptibilityen_US
dc.subjectbrain structureen_US
dc.subjectdepressionen_US
dc.subjectDifferential Susceptibilityen_US
dc.subjectSocioeconomic-Statusen_US
dc.subjectHippocampal Volumeen_US
dc.subjectEnvironmenten_US
dc.subjectContexten_US
dc.subjectRewarden_US
dc.subjectRisken_US
dc.titleThe Role of Educational Attainment and Brain Morphology in Major Depressive Disorder: Findings From the ENIGMA Major Depressive Disorder Consortiumen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu