Right ventricular free-wall longitudinal speckle tracking strain in patients with pulmonary arterial hypertension under specific treatment

Basit Öğe Kaydı
dc.contributor.authorKemal, Hatice S.
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorKultursay, Hakan
dc.contributor.authorVuran, Ozcan
dc.contributor.authorNalbantgil, Sanem
dc.contributor.authorMogulkoc, Nesrin
dc.contributor.authorCan, Levent
dc.date.accessioned2019-10-27T11:09:28Z
dc.date.available2019-10-27T11:09:28Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Right ventricular (RV) dysfunction is a major determinant of outcomes in patients with pulmonary arterial hypertension (PAH), although the optimal measure of RV function is poorly defined. We evaluated the utility of RV free-wall speckle tracking strain as an assessment tool for RV function in patients with PAH who are already under specific treatment compared with conventional echocardiographic parameters and investigated the relationship of RV free-wall strain with clinical hemodynamic parameters of RV performance. Methods Right ventricular free-wall strain was evaluated in 92 patients (Group-1 and Group-4 pulmonary hypertension) who were on PAH-specific treatment for at least 3 months. Right atrial (RA) area, RV FAC, TAPSE, tricuspid S, functional class, 6-minute walking distance, and NT-proBNP were studied. The mean duration of follow-up was 222 +/- 133 days. Results All patients were under PAH-specific treatment, and mean RV free-wall strain was -13.16 +/- 6.3%. RV free-wall strain correlated well with functional class (r=.312, P=.01), NT-proBNP (r=.423, P=.0001), RA area (r=.427, P=.0001), FAC (r=-.637, P=.0001), TAPSE (r=-.524, P=.0001), tricuspid S (r=-.450, P=.0001), 6-minute walking distance (r=-.333, P=.002). RV free-wall strain significantly correlated with all follow-up adverse events, death, and clinical right heart failure (RHF) (P=.04, P=.03, P=.02, respectively). According to the receiver operator characteristic analysis, the cutoff value for RV free-wall strain for the development of clinical RHF was -12.5% (sensitivity: 71%, specificity: 67%) and for all cardiovascular adverse events (death included) was -12.5% (sensitivity: 54%, specificity: 64%). Conclusion Assessment of RV free-wall strain is a feasible, easy-to-perform method and may be used as a predictor of RHF, clinical deterioration, and mortality in patients already under PAH-specific treatment.en_US
dc.identifier.doi10.1111/echo.13472en_US
dc.identifier.endpage536en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue4en_US
dc.identifier.pmid28332221en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org/10.1111/echo.13472
dc.identifier.urihttps://hdl.handle.net/11454/32292
dc.identifier.volume34en_US
dc.identifier.wosWOS:000398579100007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectechocardiographyen_US
dc.subjectpulmonary arterial hypertensionen_US
dc.subjectright ventricle functionen_US
dc.subjectstrainen_US
dc.titleRight ventricular free-wall longitudinal speckle tracking strain in patients with pulmonary arterial hypertension under specific treatmenten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu