Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues

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dc.contributor.authorPuskullu, M. Orhan
dc.contributor.authorShirinzadeh, Hanif
dc.contributor.authorNenni, Merve
dc.contributor.authorGurer-Orhan, Hande
dc.contributor.authorSuzen, Sibel
dc.date.accessioned2019-10-27T23:11:52Z
dc.date.available2019-10-27T23:11:52Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractOverproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known that the use of antioxidants could be beneficial in the prevention or delay of numerous diseases associated with oxidative stress. Melatonin (MLT) is known as a powerful free-radical scavenger and antioxidant. It was found that indole ring of MLT can be employed by bioisosteric replacement by other aromatic rings. Quinoline derivatives constitute an important class of compounds for new drug development. Owing to quinoline and hydrazones appealing physiological properties and are mostly found in numerous biologically active compounds a series of quinoline-2-carbaldehyde hydrazone derivatives were synthesized as bioisosteric analogues of MLT, characterized and in vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox-sensitive fluorescent probe. Cytotoxicity potential of all compounds was investigated both by lactate dehydrogenase leakage assay and by MTT assay.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) Research and Development GrantTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112S599]; TUBITAK GrantTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108S202]en_US
dc.description.sponsorshipThe authors report no conflicts of interest. The chemical compounds of this work were supported by The Scientific and Technological Research Council of Turkey (TUBITAK) Research and Development Grant 112S599. The cell culture facility was established by the support of TUBITAK 108S202 Grant.en_US
dc.identifier.doi10.3109/14756366.2015.1005012en_US
dc.identifier.endpage125en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue1en_US
dc.identifier.pmid25942363en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2015.1005012
dc.identifier.urihttps://hdl.handle.net/11454/53140
dc.identifier.volume31en_US
dc.identifier.wosWOS:000367555300014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjecthydrazoneen_US
dc.subjectlactate dehydrogenase leakageen_US
dc.subjectmelatoninen_US
dc.subjectMTTen_US
dc.subjectquinolineen_US
dc.titleSynthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analoguesen_US
dc.typeArticleen_US

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