Medicolegal aspects of blood-urine toluene and urinary ortho-cresol concentrations in toluene exposure

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dc.contributor.authorAkgür S.A.
dc.contributor.authorÖztürk P.
dc.contributor.authorKurtulmuş Y.
dc.contributor.authorKarali H.
dc.contributor.authorErtürk S.
dc.date.accessioned2019-10-27T00:25:16Z
dc.date.available2019-10-27T00:25:16Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractToluene is a widely used solvent in different industrial areas and has a depressant effect on the central nervous system. In medicolegal cases, for the possible influence of toluene on actions or conditions prior to death, a reliable indicator of exposure must be precisely investigated. We developed an appropriate method for toluene analysis and investigate the blood-urine toluene levels and urinary ortho-cresol levels in toluene-exposed workers. Blood and urine toluene levels from 50 male subjects were detected by Gas Chromatography-FID (GC-FID) using the head-space method, and urinary o-cresol levels, a metabolite of toluene, were analyzed by GC. The significance of difference of ocresol/creatinine levels was evaluated by the nonparametric statistics Kruskal-Wallis One Way Anova, and correlation and regression statistics were determined by Pearson Correlation of bivariant analysis. The toluene concentrations in blood ranged from 0.07 to 2.12 mg/g. Urinary o-cresol levels were not correlated significantly with blood or urine toluene levels. There was no significant difference for ortho-cresol/creatinine levels between the control and worker groups. It is concluded that for medicolegal purposes, urine toluene and urinary o-cresol levels are not reliable markers, and direct toluene analysis in blood must be preferrred in toluene exposure.en_US
dc.identifier.endpage419en_US
dc.identifier.issn1300-0144
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://hdl.handle.net/11454/23221
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectForensic toxicologyen_US
dc.subjectOrtho-cresolen_US
dc.subjectTolueneen_US
dc.subjectToluene abuseen_US
dc.subjectToluene exposureen_US
dc.titleMedicolegal aspects of blood-urine toluene and urinary ortho-cresol concentrations in toluene exposureen_US
dc.typeArticleen_US

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