Serum lipid and lipoprotein composition in infants of diabetic mothers

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dc.contributor.authorAkisü M.
dc.contributor.authorDarcan S.
dc.contributor.authorOral R.
dc.contributor.authorKültürsay N.
dc.date.accessioned2019-10-27T00:27:15Z
dc.date.available2019-10-27T00:27:15Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractDiabetes mellitus (DM) alters carbohydrate and lipid metabolism to a great extent. This study was planned to determine whether infants of insulin dependent and gestational diabetic mothers have abnormal lipid metabolism. Three groups of newborns were included in the study; group I consisted of 7 infants of diabetic mothers (IDM) with insulin dependent DM (Type 1 DM), group II of 18 infants of gestational diabetic mothers and group III of 20 control neonates whose mothers had no history of DM. Total cholesterol (TC), triglyceride (TG) and high density lipoprotein-cholesterol (HDL-C) values in groups I and II were no different compared to those in group III (p > 0.05). However, low density lipoprotein-cholesterol (LDL-C) and LDL-C/HDL-C ratio were similar between groups I and II (p > 0.05) but significantly higher in both infants of type I diabetic mothers and gestational diabetic mothers compared to control infants (p < 0.05). Apolipoprotein A-I (Apo A-1) and apolipoprotein B (Apo B) levels, Apo A-I/Apo B and HDL-C/Apo A-I ratios were similar in between groups. However, Apo B/LDL-C ratio was significantly lower in groups I and II compared to control group (p < 0.05). In conclusion, diabetes in pregnant women causes a tendency to LDL hypercholesterolemia in the offspring. These infants should be longitudinally followed up to assess whether this observation imposes an increased risk for atherosclerosis for advanced ages.en_US
dc.identifier.doi10.1007/BF02845529en_US
dc.identifier.endpage386en_US
dc.identifier.issn0019-5456
dc.identifier.issue3en_US
dc.identifier.pmid10798086en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.1007/BF02845529
dc.identifier.urihttps://hdl.handle.net/11454/23502
dc.identifier.volume66en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherThe Indian Journal of Pediatricsen_US
dc.relation.ispartofIndian Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLipiden_US
dc.subjectLipoproteinen_US
dc.subjectNewbornen_US
dc.titleSerum lipid and lipoprotein composition in infants of diabetic mothersen_US
dc.typeArticleen_US

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