BCG-osis and tuberculosis in a child with chronic granulomatous disease

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dc.contributor.authorBustamante, Jacinta
dc.contributor.authorAksu, Guzide
dc.contributor.authorVogt, Guillaume
dc.contributor.authorDe Beaucoudrey, Ludovic
dc.contributor.authorGenel, Ferah
dc.contributor.authorChapgier, Ariane
dc.contributor.authorFilipe-Santos, Orchide
dc.contributor.authorFeinberg, Jacqueline
dc.contributor.authorEmile, Jean-Francois
dc.contributor.authorKutukculer, Necil
dc.contributor.authorCasanova, Jean-Laurent
dc.date.accessioned2019-10-27T19:33:40Z
dc.date.available2019-10-27T19:33:40Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractA few known primary immunodeficiencies confer predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG vaccines (regional disease, known as BCG-itis, or disseminated disease, known as BCG-osis), or more virulent mycobacteria, such as Mycobacterium tuberculosis (pulmonary and disseminated tuberculosis). We investigated the clinical and genetic features of a 12-year-old boy with both recurrent BCG-osis and disseminated tuberculosis. The patient's phagocytic cells produced no 0(2)(-). A hemizygous splice mutation was found in intron 5 of CYBB, leading to a diagnosis of X-linked chronic granulomatous disease. Chronic granulomatous disease should be suspected in all children with BCG-osis, even in the absence of nonmycobacterial infectious diseases, and in selected children with recurrent BCG-itis or severe tuberculosis.en_US
dc.identifier.doi10.1016/j.jaci.2007.04.034en_US
dc.identifier.endpage38en_US
dc.identifier.issn0091-6749
dc.identifier.issue1en_US
dc.identifier.pmid17544093en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1016/j.jaci.2007.04.034
dc.identifier.urihttps://hdl.handle.net/11454/39508
dc.identifier.volume120en_US
dc.identifier.wosWOS:000248066400004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBCGen_US
dc.subjecttuberculosisen_US
dc.subjectchronic granulomatous diseaseen_US
dc.titleBCG-osis and tuberculosis in a child with chronic granulomatous diseaseen_US
dc.typeArticleen_US

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