Sodium tungstate alleviates biomechanical properties of diabetic rat femur via modulation of oxidative stress

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dc.contributor.authorDonmez, Bans O.
dc.contributor.authorOzturk, Nihal
dc.contributor.authorSarikanat, Mehmet
dc.contributor.authorOguz, Nurettin
dc.contributor.authorSari, Ramazan
dc.contributor.authorOzdemir, Semir
dc.date.accessioned2019-10-27T22:12:56Z
dc.date.available2019-10-27T22:12:56Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractDiabetes mellitus leads to bone disorders such as osteopenia and osteoporosis that can increase fracture risk. On the other hand, sodium tungstate is an inorganic compound which exerts anti-diabetic activity in experimental studies due to its suggested insulin-mimetic or antioxidant activity. Therefore this study was designed to investigate the effect of tungstate on bone quality in diabetic rat femurs. The rats were divided into four groups: Control (C), tungstate-treated control (C+Tung), diabetes (STZ-D) and tungstate-treated diabetes (STZ-D+Tung). Diabetes mellitus was induced by single injection of streptozotocin (50 mg/kg). The treated rats received 150 mg/kg/day of sodium tungstate for 12 weeks. Sodium tungstate achieved a little (17%) but significant reduction on blood glucose levels, while it didn't recover the reduced body weights of diabetic rats. In addition, impaired bone mechanical quality was reversed, despite the unchanged mineral density. Sodium tungstate administration significantly lowered the 2-thiobarbituric acid reactive substances and restored the activity of tissue antioxidant enzymes such as glutathione peroxidase, catalase and superoxide dismutase in diabetic rats. On the other hand, glutathione levels didn't change in either case. These findings indicate that tungstate can improve the reduced mechanical quality of diabetic rat femurs due probably to reduction of reactive oxygen species and modulation of antioxidant enzymes as well as reduction in blood glucose levels.en_US
dc.description.sponsorshipAkdeniz University Scientific Research Coordination UnitAkdeniz Universityen_US
dc.description.sponsorshipThis study was supported by Akdeniz University Scientific Research Coordination Unit grant.en_US
dc.identifier.doi10.4149/gpb_2014020en_US
dc.identifier.endpage452en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue4en_US
dc.identifier.pmid25032510en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage443en_US
dc.identifier.urihttps://doi.org/10.4149/gpb_2014020
dc.identifier.urihttps://hdl.handle.net/11454/49644
dc.identifier.volume33en_US
dc.identifier.wosWOS:000342714800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeneral Physiol And Biophysicsen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic osteopeniaen_US
dc.subjectSodium tungstateen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidantsen_US
dc.subjectBone qualityen_US
dc.subjectMechanical strengthen_US
dc.titleSodium tungstate alleviates biomechanical properties of diabetic rat femur via modulation of oxidative stressen_US
dc.typeArticleen_US

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