Ameliorative effect of edible Halopteris scoparia against cadmium-induced reproductive toxicity in male mice: A biochemical and histopathologic study

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dc.contributor.authorGuner, Ozlem
dc.contributor.authorGuner, Adem
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorKarabay Yavasoglu, Nefise Ulku
dc.contributor.authorKavlak, Oya
dc.date.accessioned2020-12-01T12:01:36Z
dc.date.available2020-12-01T12:01:36Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractCadmium (Cd) is a toxic metal affecting the reproductive system. Halopteris scoparia (brown algae) is generally consumed as a salad in the Far East countries. This study was conducted to compare and determine the possible protective effects of H. scoparia and vitamin E and C combination (VEC) against cadmium chloride (CdCl2)-induced reproductive toxicity. A total of 36 male mice were equally divided into as control, CdCl2 (2 mg/kg), CdCl2 + H. scoparia (900 mg/kg), CdCl2 + VEC (200 mg/kg), H. scoparia alone and VEC alone groups. Blood and testis samples were taken for biochemical, histochemical and immunohistochemical analyses. H. scoparia was also examined for antioxidant activity (by DPPH assay) and mineral/trace element content (by ICP-MS method). CdCl2 exposure caused a significant deterioration in body weight, sperm parameters (count, motility, viability and morphology) (p < .001), histopathology, immunoreactivity and testosterone levels. However, H. scoparia improved CdCl2-induced deterioration effects more successfully than VEC-treated group. the present study suggests that edible H. scoparia can be used as a natural protective agent against Cd-induced testicular damage by possibly enhancing essential element levels or increasing antioxidant defence system.en_US
dc.identifier.doi10.1111/and.13591en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid32320493en_US
dc.identifier.scopus2-s2.0-85084053018en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13591
dc.identifier.urihttps://hdl.handle.net/11454/62466
dc.identifier.volume52en_US
dc.identifier.wosWOS:000527925600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalgaeen_US
dc.subjectcadmiumen_US
dc.subjectoxidative stressen_US
dc.subjectprotective effecten_US
dc.subjecttestisen_US
dc.titleAmeliorative effect of edible Halopteris scoparia against cadmium-induced reproductive toxicity in male mice: A biochemical and histopathologic studyen_US
dc.typeArticleen_US

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