PON192 Polymorphism and LDL-Oxidation As Risk Factors For Coronary Artery Disease in Young Turkish Population

Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as a risk factor for cardiovascular disease. It's been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles. Nevertheless recent publications showed major differences of PON1 activity and concentration in different populations. We aimed to study low-density-lipoprotein (LDL) oxidation and PON1 activities (paraoxonase/arylesterase) regarding to PON192 polymorphism, in order to determine if they might be useful markers especially for young patients with coronary artery disease in Turkish population. Methods: 60 patients (38.1 +/- 5.0 years) with coronary artery disease and 52 healthy control subjects (32.5 +/- 6.1 years) were taken into study. Paraoxonase192 polymorphism, paraoxonase activity and oxidation status of all patients were analyzed. Results: Total cholesterol, triglyceride, basal-LDL-diene and stimulated-LDL-TBARS levels were higher, paraoxonase and arylesterase activities were lower in patients with coronary artery disease compared to controls(p<0.001). While there was no difference in any parameters within control group in regard to polymorphism, stimulated-LDL TBARS levels were higher in patients with RR polymorphism (5,2 +/- 2,4 nmol/mg LDL protein for RR; 3,64 +/- 1.28 nmol/mg LDL protein for QR and 4,95 +/- 2,8 nmol/mg LDL protein for QQ). RR polymorphism was more common in patient group than controls but not statistically significant. Conclusion: Our data suggest that presence of RR polymorphism might be a predictive marker for determination of atherosclerosis in early ages.