PON192 Polymorphism and LDL-Oxidation As Risk Factors For Coronary Artery Disease in Young Turkish Population
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as a risk factor for cardiovascular disease. It's been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles. Nevertheless recent publications showed major differences of PON1 activity and concentration in different populations. We aimed to study low-density-lipoprotein (LDL) oxidation and PON1 activities (paraoxonase/arylesterase) regarding to PON192 polymorphism, in order to determine if they might be useful markers especially for young patients with coronary artery disease in Turkish population. Methods: 60 patients (38.1 +/- 5.0 years) with coronary artery disease and 52 healthy control subjects (32.5 +/- 6.1 years) were taken into study. Paraoxonase192 polymorphism, paraoxonase activity and oxidation status of all patients were analyzed. Results: Total cholesterol, triglyceride, basal-LDL-diene and stimulated-LDL-TBARS levels were higher, paraoxonase and arylesterase activities were lower in patients with coronary artery disease compared to controls(p<0.001). While there was no difference in any parameters within control group in regard to polymorphism, stimulated-LDL TBARS levels were higher in patients with RR polymorphism (5,2 +/- 2,4 nmol/mg LDL protein for RR; 3,64 +/- 1.28 nmol/mg LDL protein for QR and 4,95 +/- 2,8 nmol/mg LDL protein for QQ). RR polymorphism was more common in patient group than controls but not statistically significant. Conclusion: Our data suggest that presence of RR polymorphism might be a predictive marker for determination of atherosclerosis in early ages.
Açıklama
Anahtar Kelimeler
atherosclerosis, paraoxonase, arylesterase, PON192 polymorphism, LDL oxidation, Turkish population
Kaynak
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
34
Sayı
4
