Neurobehavioral effects of long-term maternal fructose intake in rat offspring

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dc.contributor.authorErbas, Oytun
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorKhalilnezhad, Asghar
dc.contributor.authorGurkan, Fulya Tuzcu
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorMeral, Ayfer
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-10-27T10:01:30Z
dc.date.available2019-10-27T10:01:30Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Previous studies have indicated an association between maternal metabolic conditions and general developmental disturbances of the offspring. Objective: We aimed to investigate the influence of long-term maternal fructose intake during gestation and lactation on neurobehavioral development of rat offspring. Methods: Twelve female Sprague Dawley rats were received either 30% fructose enriched water (n = 6) or regular tap water (control, n = 6) for 12 weeks. Then, control and fructose-received females were caged with a fertile male, and received 30% fructose and regular chow throughout pregnancy, delivery and until offspring's weaning. On P21, forty littermates (10 male control, 10 female control, 10 male fructose and 10 female fructose) were separated and housed with ad libitum access to standard food and tap water. Following behavioral evaluations at P50, brain levels of TNF-alpha, neuregulin 1 (NRG1), glutamic acid decarboxylase 67 (GAD67), nerve growth factor (NGF), insulin-like growth factor 1 (IGF-1), and 5-hydroxyindoleacetic acid (5-HIAA) were measured. Histologically, hippocampal neuronal density and GFAP expression were assessed. Results: Analysis of the behavioral tests (three-chamber social test, open field test, passive avoidance learning test and stereotypy test) revealed significant differences among the groups. Histologically, hippocampal CA1 and CA3 regions displayed significant alterations such as gliosis and neuronal cell death in fructose-exposed groups compare to controls. Biochemical measurements of the brain levels of TNF-alpha and neurodevelopmental markers showed significant differences between controls and fructose-exposed groups. Conclusion: These results suggest a possible link between the chronic maternal metabolic stress, such as long-term fructose intake, and neurodevelopmental disturbances in the offspring.en_US
dc.identifier.doi10.1016/j.ijdevneu.2018.07.001en_US
dc.identifier.endpage79en_US
dc.identifier.issn0736-5748
dc.identifier.issn1873-474X
dc.identifier.pmid30004004en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijdevneu.2018.07.001
dc.identifier.urihttps://hdl.handle.net/11454/29859
dc.identifier.volume69en_US
dc.identifier.wosWOS:000444659700009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofInternational Journal of Developmental Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism spectrum disordersen_US
dc.subjectFructose exposureen_US
dc.subjectTNF-alphaen_US
dc.subjectNeuregulin 1en_US
dc.subjectNGFen_US
dc.subjectGAD67en_US
dc.subject5HIAAen_US
dc.subjectIGF1en_US
dc.titleNeurobehavioral effects of long-term maternal fructose intake in rat offspringen_US
dc.typeArticleen_US

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