Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment

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dc.contributor.authorAkagunduz, O.
dc.contributor.authorKaraca, B.
dc.contributor.authorAtmaca, H.
dc.contributor.authorUzunoglu, S.
dc.contributor.authorKarabulut, B.
dc.contributor.authorSanli, U. A.
dc.contributor.authorHaydaroglu, A.
dc.contributor.authorUslu, R.
dc.date.accessioned2019-10-27T21:14:38Z
dc.date.available2019-10-27T21:14:38Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: Many drugs have been tested to increase the sensitivity of prostate cancer cells to radiotherapy Gossypol, a natural polyphenolic compound extracted from the cotton plant, is one of the agents the efficacy of which has been investigated in the treatment of prostate cancer for this purpose. The main aim of this study was to investigate the best gossypol application with irradiation, when gossypol was applied either sequentially (24 h before and after irradiation) or concurrently in PC-3 hormone-refractory and radioresistant prostate cancer cells. Methods: The XTT viability assay was used to evaluate the cytotoxicity of different concentrations of gossypol in PC-3 cells. Irradiation was applied to PC-3 cells via 6 MV photon linear accelerator and delivered 24 h before, 24 h after radiation or at the same time with gossypol administration. Results: Gossypol caused radiosensitization of PC-3 cells that are known to be radioresistant, with high Bcl-2 levels. Among different applications of gossypol and irradiation (before, after and concurrent) in prostate cancer cells, the best results were observed by the application of gossypol 24 h before irradiation. Conclusion: Our study suggests that gossypol represents a promising novel anticancer treatment for radiosensitization of human hormone-refractory prostate cancer cells.en_US
dc.identifier.endpage767en_US
dc.identifier.issn1107-0625
dc.identifier.issue4en_US
dc.identifier.pmid21229643en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage763en_US
dc.identifier.urihttps://hdl.handle.net/11454/43418
dc.identifier.volume15en_US
dc.identifier.wosWOS:000286539800022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZerbinis Medical Publen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBc1-2en_US
dc.subjectgossypolen_US
dc.subjectPC-3 prostate cancer cellsen_US
dc.subjectradiosensitizationen_US
dc.subjectradiotherapyen_US
dc.titleRadiosensitization of hormone-refractory prostate cancer cells by gossypol treatmenten_US
dc.typeArticleen_US

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