Evaluation of treatment results and prognostic factors in early-stage cervical carcinoma patients treated with postoperative radiotherapy or radiochemotherapy

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dc.contributor.authorDemirci, S.
dc.contributor.authorOzsaran, Z.
dc.contributor.authorOzsaran, A.
dc.contributor.authorYavas, F.
dc.contributor.authorDemircioglu, B.
dc.contributor.authorHanhan, M.
dc.contributor.authorDikmen, Y.
dc.contributor.authorAras, A. B.
dc.date.accessioned2019-10-27T21:34:37Z
dc.date.available2019-10-27T21:34:37Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To investigate the clinical features, prognostic factors, and treatment outcome in early-stage cervical carcinoma patients treated with postoperative radiotherapy (RT)/radiochemotherapy (RCT). Methods: The records of 256 Stage IB and 11 cervical cancer patients treated with postoperative RT/RCT from 1992-2007 were retrospectively reviewed. Median age of the patients was 47 (range: 25-78). Two hundred one (78.6%) patients had squamous cell carcinoma and 29(11.3%) had adenocarcinoma. One hundred and eighty-seven (73.0%) had FIGO Stage IB and 69 (27%) had Stage II disease. Concomitant cisplatin-based chemotherapy was administered to 47 (18.4%) patients. Metastatic lymph node ratio (MLNR), defined as number of metastatic lymph nodes divided by the number of dissected lymph nodes, was 0 in 142 (55.5%) patients, from 1% to 10% in 27 (10.5%) and > 10% in 31(12.1%) patients. Results: Median follow-up duration was 60.5 months (range: 6-202 months). Five-year locoregional control (LRC), disease-free survival (DFS), disease specific survival (DSS) and overall survival (OS) rates were 90.8%, 83.4%, 91.2%, and 85%, respectively. In multivariate analysis; bulky tumor (> 4 cm) was shown as an important prognostic factor for LRC, DFS and DSS. Pretreatment hemoglobin level (< 10 g/dl) was associated with lower OS rate. Endometrial involvement was associated with lower LRC and DFS. Treatment break > 14 days showed significance for DFS and DSS. MLNR was found as a valuable prognostic factor for all endpoints (LRC, DFS, DSS and OS). The rate of grade 3-4 late toxicity was 3.6% and 2%, respectively. Conclusion: Postoperative RT/RCT is an effective treatment modality for early-stage cervical cancer patients with unfavorable features and provides satisfactory local control and survival rates with low morbidity.en_US
dc.identifier.endpage67en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.pmid22439408en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/11454/45640
dc.identifier.volume33en_US
dc.identifier.wosWOS:000300253400011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervical canceren_US
dc.subjectRadiotherapyen_US
dc.subjectRadiochemotherapyen_US
dc.subjectPrognostic factorsen_US
dc.subjectMetastatic lymph node ratioen_US
dc.subjectSide-effectsen_US
dc.titleEvaluation of treatment results and prognostic factors in early-stage cervical carcinoma patients treated with postoperative radiotherapy or radiochemotherapyen_US
dc.typeArticleen_US

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