Effect of vascular endothelial growth factor on fetal vessels among obese pregnant women

Basit Öğe Kaydı
dc.contributor.authorJanbakhishov, Turab
dc.contributor.authorCaglayan, Erkan
dc.contributor.authorAcet, Ferruh
dc.contributor.authorAltunyurt, Sabahattin
dc.contributor.authorOzer, Erdener
dc.date.accessioned2020-12-01T11:58:06Z
dc.date.available2020-12-01T11:58:06Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective To determine the role of vascular endothelial growth factor (VEGF) in placental hypoperfusion in obesity. Methods the prospective study enrolled women with a first-trimester singleton pregnancy in Izmir, Turkey, between January and April 2011. Participants were divided into three groups: obese (body mass index [BMI, calculated as weight in kilograms divided by the square of height in meters] >30) with cesarean delivery; normal weight (BMI <30) with vaginal delivery (NVD); and healthy controls (BMI <30) with cesarean delivery. Before delivery, serum C-reactive protein (CRP), and uterine and fetal Doppler measurements were taken. VEGF was evaluated immunohistochemically from the umbilical cord. Results Overall, 109 women completed the study: obesity group (n=13, 11.9%), NVD group (n=50, 45.9%), and control group (n=46, 42.2%). Serum CRP was higher in the obesity group than in the control or NVD groups (P=0.009). VEGF score was highest in the NVD group (9.39 +/- 3.11), and lowest in the obesity group (4.58 +/- 2.78) (P<0.001). VEGF score decreased by 0.81 for each increase in BMI of 1 (P=0.002). Conclusions Maternal obesity was related to decreased VEGF expression. Although not supported by Doppler findings, decreased VEGF expression owing to maternal obesity might trigger endothelial dysfunction and inflammation.en_US
dc.identifier.doi10.1002/ijgo.13346en_US
dc.identifier.endpage236en_US
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue2en_US
dc.identifier.pmid32790905en_US
dc.identifier.scopus2-s2.0-85090439511en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1002/ijgo.13346
dc.identifier.urihttps://hdl.handle.net/11454/61924
dc.identifier.volume151en_US
dc.identifier.wosWOS:000567697500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Gynecology & Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFetal vasculatureen_US
dc.subjectObesityen_US
dc.subjectPlacental vascularityen_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectVEGFen_US
dc.titleEffect of vascular endothelial growth factor on fetal vessels among obese pregnant womenen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu