Prognostic impact of mitosis and necrosis in non-mucinous lung adenocarcinomas and correlation with IASLC grading system

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dc.authoridSerin, Gürdeniz/0000-0003-4204-0601
dc.authoridISGOR, IREM SAHVER/0000-0001-7996-2250
dc.authoridMIZRAK, ali/0000-0002-1096-1660
dc.contributor.authorSerin, Gurdeniz
dc.contributor.authorSavas, Pinar
dc.contributor.authorIsgor, Irem Sahver
dc.contributor.authorOzdil, Ali
dc.contributor.authorMizrak, Ali
dc.contributor.authorVeral, Ali
dc.contributor.authorNart, Deniz
dc.date.accessioned2024-08-31T07:49:38Z
dc.date.available2024-08-31T07:49:38Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. In 2020, the International Lung Cancer Study Group (IASLC) Pathology Committee established a grading system for non-mucinous primary lung adenocarcinomas. This grading system is based on whether areas of high-grade patterns are present in more than 20% of the tumor. Parameters, such as necrosis, mitotic activity, lymphovascular invasion (LVI) and spread through air spaces (STAS), are excluded from evaluating the grading system. Methods. A total of 217 patients' lung resection materials for primary lung adenocarcinoma were rereviewed using the IASLC grading system. Necrosis, mitotic activity, LVI status and STAS were also evaluated in the resection materials, aiming to demonstrate the relationship between these histopathological features and clinical outcome data. Results. At all stages, overall survival (OS) and recurrence -free survival (RFS) were related to grade ( p =0.011 and 0.024, respectively). Additionally, patients with necrosis were associated with worse OS and RFS ( p =0.002 and 0.048, respectively). When grade 2 and 3 tumors were analyzed individually, a significant relationship was found between necrosis and OS in grade 3 tumors ( p =0.002). Patients with a high mitotic count (>= 10/10 high -power fields) had significantly worse OS ( p =0.046). The prevalence of LVI and STAS increased with grade; however, their prognostic significance has not been demonstrated. Conclusions. The new grading system provides a highly efficient prognostic classification for survival. Necrosis and high mitotic count are important prognostic parameters for survival. Additionally, necrosis is a stageindependent prognostic factor for OS in grade 3 tumors, although no effect on prognosis can be demonstrated in grade 2 tumors.en_US
dc.identifier.doi10.14670/HH-18-661
dc.identifier.endpage714en_US
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue6en_US
dc.identifier.pmid37724635en_US
dc.identifier.scopus2-s2.0-85194013463en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org/10.14670/HH-18-661
dc.identifier.urihttps://hdl.handle.net/11454/104924
dc.identifier.volume39en_US
dc.identifier.wosWOS:001241679100003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherF Hernandezen_US
dc.relation.ispartofHistology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectLung Adenocarcinomaen_US
dc.subjectGrading Systemsen_US
dc.subjectNecrosisen_US
dc.subjectMitosisen_US
dc.titlePrognostic impact of mitosis and necrosis in non-mucinous lung adenocarcinomas and correlation with IASLC grading systemen_US
dc.typeArticleen_US

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