Cord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosis

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dc.contributor.authorGunes, Sezgin
dc.contributor.authorYalaz, Mehmet
dc.contributor.authorSozmen, Eser
dc.contributor.authorAltun Koroglu, Ozge
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2019-10-27T20:24:36Z
dc.date.available2019-10-27T20:24:36Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackgroundThe aim of this study was to investigate the relationship between plasma chitotriosidase activity, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity and mortality in premature infants. MethodsCord blood chitotriosidase activity was studied in healthy control infants (53 term, group 1; 26 late preterm [33-37gestational weeks], group 2) and 35 preterm infants (32weeks; group 3). In group 3, consecutive samples at 3h, 24h, 72h, 7days, 14days, and 36weeks after conception were also analyzed. Group 3 was also evaluated for mortality, respiratory treatment and bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). ResultsCord blood chitotriosidase activity was positively correlated with gestational age and birthweight. SNAPPE-II score was correlated with chitotriosidase activity at 24h. Consecutive chitotriosidase activity for group 3 was non-significantly higher in infants who died in the early neonatal period. Higher chitotriosidase activity was observed in mechanically ventilated infants than infants treated with non-invasive assisted ventilation. BPD, PDA, IVH and ROP, but not NEC, were related to higher chitotriosidase activity, being significant at some of the time points. ConclusionNeonatal stress such as invasive ventilation may create a risk for the development of BPD, PDA, IVH, and ROP by increasing macrophage activation in preterm infants as reflected in the higher chitotriosidase activity. High chitotriosidase activity may also be associated with disease severity and mortality.en_US
dc.description.sponsorshipEge University Faculty of Medicine, Izmir, TurkeyEge University [2012-TIP-012]en_US
dc.description.sponsorshipWe thank Professor Mehmet Orman from the Department of Biostatistics, Ege University Faculty of Medicine, for his assistance with analysis and presentation of data. This study was supported by a grant (2012-TIP-012) to M.Y. from the Ege University Faculty of Medicine, Izmir, Turkey. No authors have any conflict of interest to declare.en_US
dc.identifier.doi10.1111/ped.12532en_US
dc.identifier.endpage421en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue3en_US
dc.identifier.pmid25367205en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage414en_US
dc.identifier.urihttps://doi.org/10.1111/ped.12532
dc.identifier.urihttps://hdl.handle.net/11454/42148
dc.identifier.volume57en_US
dc.identifier.wosWOS:000356974900014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchitotriosidaseen_US
dc.subjectmorbidityen_US
dc.subjectmortalityen_US
dc.subjectnewbornen_US
dc.subjectprematurityen_US
dc.titleCord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosisen_US
dc.typeArticleen_US

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