Pediatric langerhans cell histiocytosis: single center experience over a 17-year period

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dc.contributor.authorInce, Dilek
dc.contributor.authorDemirag, Bengu
dc.contributor.authorOzek, Gulcihan
dc.contributor.authorErbay, Ayse
dc.contributor.authorOrtac, Ragip
dc.contributor.authorOymak, Yesim
dc.contributor.authorKamer, Serra
dc.contributor.authorYaman, Yontem
dc.contributor.authorKundak, Selcen
dc.contributor.authorVergin, Canan
dc.date.accessioned2019-10-27T23:09:09Z
dc.date.available2019-10-27T23:09:09Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study aimed to analyze children with the diagnosis of Langerhans cell histiocytosis (LCH) who were diagnosed and treated between 1998-2015. Medical records were evaluated retrospectively for clinical and laboratory features, treatment details, and outcome. There were 20 patients, the median age of diagnosis was 37 months, M/F ratio: 1.5. Nine had single system (SS), 11 had multisystem (MS) LCH. Spontaneous regression occurred in three infants with skin limited LCH. Eight patients had risk organ involvement in MS-LCH group. The curettage alone was performed in only one case. Patients received LCH-II/LCH-III based chemotherapy schema. Radiotherapy was performed to vertebral disease and residual craniofacial bone disease in four cases. The regression and relapse rates were 100% and 33% for SS-LCH. The regression and relapse rates were 73%, and 18% for MS-LCH. Two infants with MS-LCH died despite chemotherapy. Pulmonary and liver involvements affected outcome adversely in MS-LCH. Multidisciplinary treatment approaches are needed.en_US
dc.identifier.endpage355en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid28276205en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage349en_US
dc.identifier.urihttps://hdl.handle.net/11454/52540
dc.identifier.volume58en_US
dc.identifier.wosWOS:000398205800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLangerhans cell histiocytosisen_US
dc.subjectchildrenen_US
dc.subjecttreatmenten_US
dc.titlePediatric langerhans cell histiocytosis: single center experience over a 17-year perioden_US
dc.typeArticleen_US

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