Hyaluronic acid-modified [F-19]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs

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dc.contributor.authorYasakci, Volkan
dc.contributor.authorTekin, Volkan
dc.contributor.authorGuldu, Ozge Kozgus
dc.contributor.authorEvren, Vedat
dc.contributor.authorUnak, Perihan
dc.date.accessioned2019-10-27T10:00:20Z
dc.date.available2019-10-27T10:00:20Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, we designed and synthesized [F-19]FDG-(2-deoxy-2-[fluorine-19]fluoro-d-glucose) conjugated iron oxide magnetic nanoparticles ([F-19]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). They were then covered with hyaluronic acid (HA) to enhance their bioavailability. The modified MNPs were conjugated with [F-19]FDG and optically labeled with ICG (indocyanine green). The in vitro bioaffinities were surveyed in MCF7 and PC3 cell lines. In vivo bioaffinies were determined using Sprague-Dawley rats.en_US
dc.identifier.doi10.1007/s10967-018-6282-6
dc.identifier.endpage1989en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue3en_US
dc.identifier.startpage1973en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-018-6282-6
dc.identifier.urihttps://hdl.handle.net/11454/29712
dc.identifier.volume318en_US
dc.identifier.wosWOS:000451746300047en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectHyaluronic aciden_US
dc.subjectFluorodeoxyglucoseen_US
dc.subjectIndocyanine greenen_US
dc.subjectTheranosticen_US
dc.titleHyaluronic acid-modified [F-19]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organsen_US
dc.typeArticleen_US

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