Hyaluronic acid-modified [F-19]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, we designed and synthesized [F-19]FDG-(2-deoxy-2-[fluorine-19]fluoro-d-glucose) conjugated iron oxide magnetic nanoparticles ([F-19]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). They were then covered with hyaluronic acid (HA) to enhance their bioavailability. The modified MNPs were conjugated with [F-19]FDG and optically labeled with ICG (indocyanine green). The in vitro bioaffinities were surveyed in MCF7 and PC3 cell lines. In vivo bioaffinies were determined using Sprague-Dawley rats.
Açıklama
Anahtar Kelimeler
Magnetic nanoparticles, Hyaluronic acid, Fluorodeoxyglucose, Indocyanine green, Theranostic
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
318
Sayı
3
