Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines

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dc.contributor.authorUzaras C.
dc.contributor.authorAvcıbaşı U.
dc.contributor.authorDemiroğlu H.
dc.contributor.authorMedine E.İ.
dc.contributor.authorKılçar A.Y.
dc.contributor.authorMüftüler F.Z.B.
dc.contributor.authorÜnak P.
dc.date.accessioned2019-10-27T08:20:55Z
dc.date.available2019-10-27T08:20:55Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the incorporations of PHT radiolabeled with 131I (131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of 131I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of 131I, 131I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of 131I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, 131I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors. © 2015, Akadémiai Kiadó, Budapest, Hungary.en_US
dc.identifier.doi10.1007/s10967-015-4119-0
dc.identifier.endpage140en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-015-4119-0
dc.identifier.urihttps://hdl.handle.net/11454/25855
dc.identifier.volume307en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDaoy and A549 cancerous cell linesen_US
dc.subjectDiphenylhydantoinen_US
dc.subjectEpilepsyen_US
dc.subjectPhenytoinen_US
dc.subjectRadiolabelingen_US
dc.subjectU-87 MGen_US
dc.titleInvestigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell linesen_US
dc.typeArticleen_US

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