Investigation of therapeutic efficiency of phenytoin (PHT) labeled with radioactive 131I in the cancer cell lines
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Netherlands
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study is to determine the incorporations of PHT radiolabeled with 131I (131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of 131I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of 131I, 131I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of 131I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, 131I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors. © 2015, Akadémiai Kiadó, Budapest, Hungary.
Açıklama
Anahtar Kelimeler
Daoy and A549 cancerous cell lines, Diphenylhydantoin, Epilepsy, Phenytoin, Radiolabeling, U-87 MG
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
307
Sayı
1
