A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma

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dc.contributor.authorDoganavsargil, B
dc.contributor.authorSimsir, A
dc.contributor.authorBoyacioglu, H
dc.contributor.authorCal, C
dc.contributor.authorHekimgil, M
dc.date.accessioned2019-10-27T19:19:22Z
dc.date.available2019-10-27T19:19:22Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractTo assess the immunoexpression of p21 and p27 proteins in consecutive areas of benign glands, prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma. Tissue from 91 patients who had a radical prostatectomy was assessed by immunohistochemistry to evaluate the expression of p21 and p27 in adjacent areas of benign glands, PIN and prostate adenocarcinoma. The results were correlated with various clinicopathological variables, e.g. age, total prostate-specific antigen level, tumour stage, Gleason score, surgical margin involvement, extraprostatic extension, seminal vesicle invasion, and perineural invasion. The p27 score in PIN was lower than that in benign glands (P = 0.04) but there was no significant difference between the scores for PIN and tumour. By contrast, p21 expression was almost undetectable in benign glands, although there was substantially more in PIN and tumour (P < 0.01). Some patients had no expression of p21 in tumour tissue, and had lower p21 scores in benign glands and PIN areas (P < 0.05). Interestingly, these patients had a lower frequency of negative prognostic variables. The tumour p21 score was higher in patients with extraprostatic extension (P = 0.045) and tumour p27 expression was inversely correlated with seminal vesicle invasion (P = 0.028). Tumour and PIN p27 expression appeared to decrease with advancing age (P = 0.008 and 0.012, respectively). Higher p21 and lower p27 expression is correlated with adverse prognostic factors. The decline in p27 with advancing age in tumour and PIN areas may be a possible explanation of the greater frequency of prostate adenocarcinoma in older men. A p21-negative tumour subgroup with a lower frequency of adverse prognostic factors was identified, which needs to be further explored.en_US
dc.identifier.doi10.1111/j.1464-410X.2006.06054.xen_US
dc.identifier.endpage648en_US
dc.identifier.issn1464-4096
dc.identifier.issue3en_US
dc.identifier.pmid16469041en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage644en_US
dc.identifier.urihttps://doi.org/10.1111/j.1464-410X.2006.06054.x
dc.identifier.urihttps://hdl.handle.net/11454/38736
dc.identifier.volume97en_US
dc.identifier.wosWOS:000235255600042en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofBju Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectprostate adenocarcinomaen_US
dc.subjectPINen_US
dc.subjectbenign glandsen_US
dc.subjectp21en_US
dc.subjectp27en_US
dc.subjectageen_US
dc.titleA comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinomaen_US
dc.typeArticleen_US

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