Serotonin transporter (5-HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation

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dc.contributor.authorKhan, H. L.
dc.contributor.authorBhatti, S.
dc.contributor.authorAbbas, S.
dc.contributor.authorKhan, Y. L.
dc.contributor.authorGonzalez, R. M. M.
dc.contributor.authorAslamkhan, M.
dc.contributor.authorGonzalez, G. R.
dc.contributor.authorAydin, H. H.
dc.date.accessioned2019-10-27T10:00:51Z
dc.date.available2019-10-27T10:00:51Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractPremature ejaculation is one of the most common sexual disorders in men due to uncontrolled modulation of spinal reflexes controlled by cortico-limbic centers in the brain. In this study, we investigate the combinatorial effects of trinucleotide repeats of androgen receptor and allelic variants of the 5-HTTLPR gene on sex steroids, hypophyseal hormones, sexual performance, and premature ejaculation assessment parameters among evidence-based lifelong premature ejaculation subjects. A total of 271 outpatients (age 26.6 +/- 1.9) consulting for evidence-based lifelong premature ejaculatory dysfunction were selected in this study. The control group consists of 155 men with normal IELT (>4 min). The study revealed that the subjects who have the highest (>= 26) CAG stretches depicted a significantly higher serum oxytocin levels (102.1 pg/ml; n = 126, p < 0.001) compared with the control group (71.2 pg/ml; n = 75, p = <0.001) and patients which have medium (22-25) and short (<= 21) CAG stretches (76.63 ng/ml; n = 64, p n = 81, p < 0.001). Almost 33 (26.1%) lifelong premature ejaculatory patients had AR variant of longer (>= 26) CAG repeats was homozygous for S alleles (SS), 45 (35.7%) was homozygous for L allele (LL), and 48 (38%) had the L/S or S/L genotype of 5-HTTLPR gene. Homozygous (SS) alleles have a significant positive correlation (r = 0.44, p < 0.0001) with the high score of BDI-II (39.1, n = 126, p < 0.001). However, LL alleles have shown a significant positive correlation with PEDT (r = 0.46, p < 0.001) and negative correlation with self-estimated IELT and intercourse satisfaction (r = -0.35, p < 0.001). The innovative study design elaborates that androgen receptor trinucleotide repeats and 5-HTTLPR genotypes have combinatorial impact on hormonal milieu and sexual function regarding evidence-based lifelong premature ejaculatory dysfunction patients.en_US
dc.identifier.doi10.1111/andr.12518en_US
dc.identifier.endpage926en_US
dc.identifier.issn2047-2919
dc.identifier.issn2047-2927
dc.identifier.issue6en_US
dc.identifier.pmid30019487en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage916en_US
dc.identifier.urihttps://doi.org/10.1111/andr.12518
dc.identifier.urihttps://hdl.handle.net/11454/29774
dc.identifier.volume6en_US
dc.identifier.wosWOS:000453888600017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5-HTTLPR genotypesen_US
dc.subjectAndrogen receptoren_US
dc.subjectLifelong PEen_US
dc.subjectOxytocinen_US
dc.subjectTestosteroneen_US
dc.subjectTri-nucleotide repeatsen_US
dc.titleSerotonin transporter (5-HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculationen_US
dc.typeArticleen_US

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