Effect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 activity in healthy people

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dc.contributor.authorSolak, ZA
dc.contributor.authorKabaroglu, C
dc.contributor.authorCok, G
dc.contributor.authorParildar, Z
dc.contributor.authorBayindir, U
dc.contributor.authorOzmen, D
dc.contributor.authorBayindir, O
dc.date.accessioned2019-10-27T19:22:48Z
dc.date.available2019-10-27T19:22:48Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThe purpose of this study was to examine the effect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 (PON1) activity in a healthy population. The study included 130 subjects who were classified as mild (<= 10 cigarettes daily, Group I, n=30), moderate (11-20 cigarettes daily, Group 11, n=35), heavy (>20 cigarettes daily, Group III, n=33) and never smokers (controls, Group IV, n=32). Malondialdehyde (MDA) levels, PON1 and erythrocyte glutathione enzyme activities were measured. MDA levels were significantly higher in smokers than never smokers (P<0.05 for Group I, P<0.001 for Group II and III). PON1 activity was significantly lower in heavy smokers (P<0.001). Glutathione peroxidase (GSH-Px) activity was significantly lower in the smokers (P<0.0001). Glutathione reductase (GR) activity was significantly higher in smokers (P<0.0001). MDA levels negatively correlated with PON1 and GSH-PX activities (P<0.01), whereas they positively correlated with GR activities (P<0.001). At every level, cigarette smoking is associated with increased lipid peroxidation and causes an impairment in antioxidant systems.en_US
dc.identifier.doi10.1007/s10238-005-0072-5en_US
dc.identifier.endpage105en_US
dc.identifier.issn1591-8890
dc.identifier.issue3en_US
dc.identifier.pmid16284731en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.1007/s10238-005-0072-5
dc.identifier.urihttps://hdl.handle.net/11454/39123
dc.identifier.volume5en_US
dc.identifier.wosWOS:000233117500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofClinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsmokingen_US
dc.subjectPON1en_US
dc.subjectMDAen_US
dc.subjectGSH-PXen_US
dc.subjectGRen_US
dc.titleEffect of different levels of cigarette smoking on lipid peroxidation, glutathione enzymes and paraoxonase 1 activity in healthy peopleen_US
dc.typeArticleen_US

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