Polycystic ovary syndrome is associated with increased osteopontin levels

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dc.contributor.authorSaklamaz, Ali
dc.contributor.authorCalan, Mehmet
dc.contributor.authorYilmaz, Ozgur
dc.contributor.authorKume, Tuncay
dc.contributor.authorTemur, Muzaffer
dc.contributor.authorYildiz, Nurdan
dc.contributor.authorKasap, Esin
dc.contributor.authorGenc, Mine
dc.contributor.authorYurekli, Banu Sarer
dc.contributor.authorKocabas, Gokcen Unal
dc.date.accessioned2019-10-27T23:10:40Z
dc.date.available2019-10-27T23:10:40Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Osteopontin (OPN) is a multi-functional secreted glycoprotein that plays a crucial role in glucose metabolism and inflammatory process. Growing evidence suggests that there is a link between OPN and ovarian function. However, no such link has yet been found for OPN in polycystic ovary syndrome (PCOS). Our aim was to ascertain whether circulating OPN levels are altered in women with PCOS and to determine whether OPN levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women. Design and methods: In total, 150 women with PCOS and 150 age-and BMI-matched controls without PCOS were recruited for this prospective observational study. OPN levels were measured using ELISA. Metabolic parameters were also determined. Results: Circulating OPN levels were significantly elevated in PCOS women compared with controls (69.12 +/- 31.59 ng/ml vs 42.66 +/- 21.28 ng/ml; P<0.001). OPN levels were significantly higher at mid-cycle than in the follicular phase in eumenorrheic women. OPN was positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free testosterone, and high sensitivity C-reactive protein (hs-CRP). Multivariate logistic regression analyses revealed that the odds ratio (OR) for PCOS was 3.64 for patients in the highest quartile of OPN compared with those in the lowest quartile (OR=3.64; 95% CI=2.42-5.57; P=0.011). Our findings indicate that BMI, HOMA-IR, hs-CRP, and free testosterone are independent factors influencing serum OPN levels and that OPN is an independent predictor for HOMA-IR. Conclusion: PCOS is associated with increased OPN levels.en_US
dc.identifier.doi10.1530/EJE-15-1074en_US
dc.identifier.endpage423en_US
dc.identifier.issn0804-4643
dc.identifier.issn1479-683X
dc.identifier.issue4en_US
dc.identifier.pmid26701868en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1530/EJE-15-1074
dc.identifier.urihttps://hdl.handle.net/11454/52940
dc.identifier.volume174en_US
dc.identifier.wosWOS:000372072300007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBioscientifica Ltden_US
dc.relation.ispartofEuropean Journal of Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePolycystic ovary syndrome is associated with increased osteopontin levelsen_US
dc.typeArticleen_US

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