Effect of pre-infarction angina on ventricular late potentials in patients with acute myocardial infarction and successful thrombolysis

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dc.contributor.authorEvrengul, H
dc.contributor.authorKayikcioglu, M
dc.contributor.authorCan, L
dc.contributor.authorPayzin, S
dc.contributor.authorKultursay, H
dc.date.accessioned2019-10-27T18:59:40Z
dc.date.available2019-10-27T18:59:40Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective - Pre-infarction angina is considered as a good clinical model of ischaemic preconditioning which facilitates myocardial protection. Late potentials (LP) have prognostic significance following acute myocardial infarction (AMI). It is also well established that thrombolytic therapy reduces the incidence of LP. Our aim was to evaluate the relationship between pre-infarction angina and LP in patients receiving successful thrombolytic therapy. Methods and results - We prospectively studied 55 patients presenting with AMI (<6 hours). All patients received thrombolytic therapy and were evaluated with coronary angiography at predischarge. Signal-averaged recordings (SAECG) were obtained serially prior to thrombolysis, 48 hours after and 10 days later. Pre-infarction angina was present in 14 (25%) patients. There were no significant differences between the clinical characteristics and angiographic findings of the groups. Baseline SAECG parameters of the groups were also similar. After thrombolysis, the 48(th) hour values of LAS (the duration of the terminal low amplitude signals), and both the loth day values of LAS and RMS (root mean square voltage of the last 40 ms of the QRS) were. significantly better in the pre-infarction angina group. The mean filtered QRS duration and RMS 40 values changed significantly at the 10(th) day recordings of patients with pre-infarction angina [QRS duration, 110 +/- 34 ms before to 91 +/- 11 ms after (p = 0.039); RMS 40,40 +/- 17 muV before to 50 +/- 14 muV after (p = 0.02)]. The incidence of LP significantly decreased after thrombolytic therapy in the pre-infarction angina group, however, this change was not observed in patients without angina. Conclusion - Presence of pre-infarction angina reduces the incidence of LP following thrombolysis in AMI. This might be explained by the possible beneficial effect of ischaemic preconditioning on the arrhythmogenic substrate.en_US
dc.identifier.doi10.2143/AC.58.4.2005286en_US
dc.identifier.endpage301en_US
dc.identifier.issn0001-5385
dc.identifier.issn1784-973X
dc.identifier.issue4en_US
dc.identifier.pmid12948034en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://doi.org/10.2143/AC.58.4.2005286
dc.identifier.urihttps://hdl.handle.net/11454/37666
dc.identifier.volume58en_US
dc.identifier.wosWOS:000184772100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Cardiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpre-infarction anginaen_US
dc.subjectthrombolytic therapyen_US
dc.subjectacute myocardial infarctionen_US
dc.subjectsignal-averaged electrocardiographyen_US
dc.subjectlate potentialsen_US
dc.titleEffect of pre-infarction angina on ventricular late potentials in patients with acute myocardial infarction and successful thrombolysisen_US
dc.typeArticleen_US

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