Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis

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dc.contributor.authorKirac, Leyla Baysal
dc.contributor.authorEkmekci, Ozgul
dc.contributor.authorYuceyar, Nur
dc.contributor.authorKocaman, Ayse Sagduyu
dc.date.accessioned2019-10-27T22:05:58Z
dc.date.available2019-10-27T22:05:58Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. The aim of our study was to investigate the frequency and pattern of cognitive impairment in patients with clinically isolated syndromes and definite diagnosis of multiple sclerosis within the last 2 years. Methods. We assessed the cognitive status of 46 patients aged 18-49 years with clinically isolated syndromes or definite diagnosis of multiple sclerosis who have onset of their symptoms within the last 2 years. Patients were matched with 40 healthy participants for age, sex, and educational level. Neuropsychological assessment was performed by stroop test, paced auditory serial addition test (PASAT), controlled oral word association test (COWAT), clock drawing test, trail making test (TMT), faces symbol test (FST). Hamilton Depression Scale and Modified Fatigue Impact Scale were used to quantify the severity of any depression and fatigue the subjects might suffer. Results. 19.6% of early MS/CIS group failed at 4 and more tests and had significant cognitive impairment focused on attention, executive functions, memory, and learning. No significant relationship was found between cognitive impairment and disability and fatigue scores. Discussion. Cognitive impairment can be present from the earliest stage of multiple sclerosis. It should be considered among the main manifestations of MS even in the earliest stages of the disease.en_US
dc.identifier.doi10.1155/2014/637694en_US
dc.identifier.issn0953-4180
dc.identifier.issn1875-8584
dc.identifier.pmid25944978en_US
dc.identifier.urihttps://doi.org/10.1155/2014/637694
dc.identifier.urihttps://hdl.handle.net/11454/48662
dc.identifier.wosWOS:000335016500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofBehavioural Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAssessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosisen_US
dc.typeArticleen_US

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