The Role of Vitamin D Receptor Polymorphisms on Dental Caries

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dc.contributor.authorCogulu, Dilsah
dc.contributor.authorOnay, Huseyin
dc.contributor.authorOzdemir, Yasemin
dc.contributor.authorAslan, Gulcin Itirli
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorEronat, Cemal
dc.date.accessioned2019-10-27T22:57:55Z
dc.date.available2019-10-27T22:57:55Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To determine the association between the ApaI, FokI, Cdx2 and TaqI polymorphisms of vitamin D receptor (VDR) gene in caries-active (high-moderate) and caries-free children. Study design: A hundred and fifty children (75 males, 75 females, mean age: 10.19 +/- 1.61 years) were included in the study. The subjects were divided into three groups as high caries risk group (DMFT, dft>4)(n=55), moderate caries risk group (DMFT, dft=1-4)(n=57) and caries-free group (n=38). From each individual, blood samples were collected and DNA was extracted. The VDR gene was genotyped for the polymorphisms ApaI, FokI, Cdx2 and TaqI using polymerase chain reaction and restriction fragment length polymorphism methods. All data were analyzed by chi-square test, Fisher's exact test and t test. Results: There was statistically sign cant difference in the frequency of TaqI genotypes (tt) between caries-active and caries-free children (p=0.029). No statistically significant differences were detected between ApaI, FokI, Cdx2 genotypes and dental caries. Conclusion: In the future, VDR gene polymorphisms may be used as a marker for the identification of patients with high caries risk.en_US
dc.identifier.endpage214en_US
dc.identifier.issn1053-4628
dc.identifier.issn1557-5268
dc.identifier.issue3en_US
dc.identifier.pmid27472568en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://hdl.handle.net/11454/51374
dc.identifier.volume40en_US
dc.identifier.wosWOS:000384850600007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal Pedodontics Incen_US
dc.relation.ispartofJournal of Clinical Pediatric Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin D receptoren_US
dc.subjectpolymorphismen_US
dc.subjectdental cariesen_US
dc.titleThe Role of Vitamin D Receptor Polymorphisms on Dental Cariesen_US
dc.typeArticleen_US

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