Synergistetes cluster A in saliva is associated with periodontitis

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dc.contributor.authorBelibasakis, G. N.
dc.contributor.authorOztuerk, V. -O.
dc.contributor.authorEmingil, G.
dc.contributor.authorBostanci, N.
dc.date.accessioned2019-10-27T22:06:59Z
dc.date.available2019-10-27T22:06:59Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and ObjectivesSynergistetes is a novel bacterial phylum consisting of gram-negative anaerobes. Increasing lines of evidence demonstrate that this phylum is associated with periodontal diseases. This study aimed to compare the presence and levels of Synergistetes clusters A and B, in saliva of patients with chronic periodontitis (CP), generalized aggressive periodontitis (G-AgP) and non-periodontitis subjects, and investigate their correlation with clinical parameters. Material and MethodsSaliva was collected from patients with CP (n=20), G-AgP (n=21) and non-periodontitis subjects (n=18). Full mouth clinical periodontal measurements were recorded. The numbers of Synergistetes cluster A and cluster B or the associated species Jonquetella anthropi were quantified by fluorescent in situ hybridization and microscopy. ResultsSynergistetes cluster A bacteria were detected more frequently, and at higher numbers and proportions in the two periodontitis groups, than the non-periodontitis control group. The prevalence was 27.7% in the control group, 85% in CP and 86% in G-AgP. Compared to the control group, the numbers were significantly higher by 12.5-fold in CP and 26.5-fold in G-AgP, whereas the difference between the two forms of periodontitis was not statistically significant. Within the total bacterial population, the proportion of this cluster was increased in CP and G-AgP compared to the control group, with the difference between the two forms of periodontitis being also significant. There was a positive correlation between the levels of Synergistetes cluster A in saliva and all full mouth clinical periodontal parameters. Nevertheless, Synergistetes cluster B bacteria and J.anthropi species were detected infrequently and at low levels in all the three subject groups. ConclusionSynergistetes cluster A, but not cluster B, bacteria are found at higher prevalence, numbers and proportions in saliva from patients with periodontitis, than non-periodontitis subjects. These findings support the association of this cluster with periodontitis.en_US
dc.identifier.doi10.1111/jre.12061en_US
dc.identifier.endpage732en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue6en_US
dc.identifier.pmid23441995en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage727en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12061
dc.identifier.urihttps://hdl.handle.net/11454/48927
dc.identifier.volume48en_US
dc.identifier.wosWOS:000326738400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfluorescent in situ hybridizationen_US
dc.subjectperiodontitisen_US
dc.subjectsalivaen_US
dc.subjectSynergistetesen_US
dc.titleSynergistetes cluster A in saliva is associated with periodontitisen_US
dc.typeArticleen_US

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