Assessment of insulin resistance in the idiopathic hirsutism

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dc.contributor.authorSarac, Fulden
dc.contributor.authorSaygili, Fusun
dc.contributor.authorOzgen, Gokhan
dc.contributor.authorTuzun, Mehmet
dc.contributor.authorYilmaz, Candeger
dc.contributor.authorKabalak, Taylan
dc.date.accessioned2019-10-27T19:37:53Z
dc.date.available2019-10-27T19:37:53Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Idiopathic hirsutism (IH) is the second most common cause of hirsutism, after polycystic ovary syndrome and occurs in about 15% of hirsute women. There are not many studies showing whether patients with IH also have insulin resistance. In the present study, we aimed to investigate the insulin sensivity in IH with non-obese and changing hormone levels during the hyperinsulinemic- euglycemic clamp. Methods: Twenty ( 20) non-obese women with IH ( Group I) ranging in age from 20 to 30 ( mean 25 8 5) years were studied. Hirsutism in women with normal testosterone ( T) levels and regular menstrual cycles is as defined IH. Twenty ( 20) healthy women (mean age 23 +/- 2 years) (Group II) were included in this study as the control group. Insulin sensitivity was assessed with modified euglycemic insulin clamp technique. Samples of prolactin, luteinizing hormone (LH), follicle-stimulating hormone, adrenocorticotropic hormone ( ACTH), dehydroepiandrosterone sulfate, cortisol, estradiol, progesterone, 17-OH progesterone (17-OHP), total T, and free T ( FT) were obtained at baseline and at 2nd hour during clamp. Results: Steady-state ( 120 min) glucose disposal rates were higher in Group II than Group I ( 7.51 +/- 0.83 vs. 5.76 +/- 1.89 mg/kg/min). Mean FT, ACTH, cortisol, LH, prolactin and 17-OHP levels were found to have decreased statistically significantly (p < 0.05) in Group I. Mean FT, ACTH, and prolactin levels were found to have decreased statistically significantly (p < 0.05) in Group II during the clamp. Mean baseline levels of FT, LH and prolactin were greater in women with hirsutism than in the control subjects ( p < 0.05). Insulin mediated glucose disposal was lower in the normal weight women with IH than in those without hirsutism. Conclusions: Mean FT, 17-OHP and dehydroepiandrosterone sulfate levels decreased during euglcemic-hyperinsulinemic clamp in IH. Copyright +/- 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000096434en_US
dc.identifier.endpage131en_US
dc.identifier.issn0378-7346
dc.identifier.issue3en_US
dc.identifier.pmid17057397en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://doi.org/10.1159/000096434
dc.identifier.urihttps://hdl.handle.net/11454/40026
dc.identifier.volume63en_US
dc.identifier.wosWOS:000244746900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinsulin resistanceen_US
dc.subjecthyperinsulinemic-euglycemic clampen_US
dc.subjectidiopathic hirsutismen_US
dc.titleAssessment of insulin resistance in the idiopathic hirsutismen_US
dc.typeArticleen_US

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